MicroRNA-132 regulates neurogenesis in the hippocampus, according to both mouse and human tissue studies. Restoring levels of microRNA-132 in mouse models of Alzheimer's disease reduces neurogenetic deficits and restores cognitive abilities, researchers say.
The function of the opioid system is connected to eating triggered by external stimuli. The findings could lead to the development of new therapies that target the opioid system to reduce obesity.
A clusterization approach allows researchers to analyze dendritic spines in new ways.
ISRIB, a synthetic molecule capable of boosting protein synthesis, restored memory function in mouse models of Alzheimer's disease and restored protein synthesis in the hippocampus.
PsychLight, a newly developed genetically encoded fluorescent sensor, helped researchers identify a psychedelic compound that acts on beneficial neural pathways to treat psychiatric disorders without the hallucinogenic effect.
A new series of studies review the roles neuroplasticity and neurogenesis play in alcohol addiction and recovery.
Neurons created as a result of adult neurogenesis mature for longer and grow larger than those created during infancy. Findings suggest adult-born neurons may have a more powerful function than those created during infancy and may play a critical role in neuroplasticity.
Aging may alter neural processes for remembering continuous real-world experiences and segmenting memories.
Anxiety may accelerate the progression of mild cognitive impairment to Alzheimer's disease. Brain scans revealed patients who progressed from MCI to Alzheimer's disease had decreased volume in the hippocampus and entorhinal cortex.
Astrocytes, not microglia, are responsible for constantly eliminating unnecessary and excessive adult synaptic connections in response to brain activity.
A newly developed biodegradable microcapsule that delivers nerve growth factor guides the development of hippocampal neurons in in-vitro experiments.