A lack of oxygen as a result of preterm birth does not cause hippocampal neurons to die but does impair hippocampal development. Hypoxia causes hippocampal cells to fail to mature normally, causing a reduction in long-term potentiation and impaired learning.
Ketamine, an anesthetics which has been commonly used as an illicit party drug, is helping people overcome depression. The drug works rapidly and provides lasting relief from depressive symptoms for weeks after exposure. Researchers are examining how ketamine works in the brain to help positively influence behavior in those with mood disorders.
Sulforaphane, a compound derived from broccoli sprouts, may be a useful new treatment for those suffering from schizophrenia. In a recent set of animal and human studies, researchers characterized novel chemical imbalances in the brain related to glutamate. Levels of glutamate, they discovered, can be altered by administering sulforaphane.
The mGlu2 receptor plays a critical role in the effectiveness of ketamine for treating depression.
Researchers have uncovered a mechanism in the BNST that senses the negative effects of alcohol and modulates the urge to drink. The study reports that when this mechanism doesn't function correctly, we lose the ability to recognize that we have had enough to drink.
Researchers have developed a new model of mitochondrial epilepsy which captures specific features observed in patients. The new model may help provide better therapies and treatments for the condition.
Increasing glutamate levels in the hippocampus helps to reduce anxiety in monkeys, a new study reports.
A new study reports brain connectivity appears to be dictated by the spatial architecture of neurons, rather than the cell type-specific cues.
A new study sheds light on why repeated concussions may contribute to the development of seizures.
Researchers report a genetic variant that prevents correct functioning of the NMDAR receptor may play a role in the development of schizophrenia.
Researchers report the CPG2 protein is significantly decreased in the brains of people with bipolar disorder and mutations in the SYNE1 gene undermines the expression of CPG2. The study shows how a set of genetic differences in those with bipolar disorder can lead to specific psychological dysfunction in synapses in the brain. The findings could help improve diagnosis of the disorder and help develop new treatments for BD.
Researchers have solves a longstanding mystery relating to perineuronal nets, giving rise to potential new treatments for epilepsy. The study reports the nets modulate electrical impulses in the brain and seizures can occur if perineuronal networks are dissolved.