Researchers upend a long-held view about the basic functioning of a key receptor molecule involved in signaling between neurons. The study describes how a compound linked to Alzheimer's disease impacts NMDA receptors and weakens synaptic connections between brain cells.
Using neuroimaging, researchers discovered glutamate levels are abnormally high in people with restless leg syndrome. The higher the level of glutamate in patients with RLS, the less sleep they were able to get.
Genetically engineered mice with a human gene for schizophrenia and who were exposed to lead early in life, exhibited behavioral and structural changes in the brain consistent with schizophrenia. Researchers believe their findings show a synergistic effect between lead exposure and the schizophrenia gene.
Researchers have developed an experimental drug, NitroMemantine, to boost brain synapses lost in Alzheimer's disease. The drug stops the destructive cascade of brain changes which destroy connections between neurons that leads to memory loss and cognitive decline.