A microscopy study revealed tau controls Fyn clustering in dendrites. The findings shed new light on how certain forms of dementia may occur.
Moral emotions are significantly more impaired than emotions without moral content in those with frontotemporal dementia (FTD). By contrast, those with Alzheimer's disease exhibit similar performance in both moral and extra-moral emotions as healthy subjects. The findings provide a novel biomarker for the diagnosis of FTD.
Researchers have engineered a vaccine using virus-like particles that target Tau tangles in mouse models of Alzheimer's disease. Following the administration of the vaccine, the mice developed antibodies that cleared tau proteins, with the response lasting for a month. The mice also showed improvements in memory based tests and had less brain shrinkage than their peers who did not receive the vaccine. This suggests the vaccine prevented apoptosis. Researchers hope to move the vaccine to human clinical trials in the future.
Chemically activating neurons and placing mice in stimulating environments reverses alterations and restores some neural connectivity in frontotemporal dementia. If translated into humans, the findings could help develop new treatments for fighting the effects of dementia in the elderly.
Inducing gamma oscillations with visual stimulation via a process known as gamma entrainment using sensory stimuli, or GENUS, was shown to reduce amyloid plaques and phosphorylated tau in mouse models of dementia. Providing GENUS daily during the early stages of neurodegeneration helps preserve neural and synaptic density across multiple brain areas and improves cognitive performance for learning and spatial memory tasks.
Researchers have identified five different subtypes of the sleep disorder insomnia, including difficulty falling asleep and early morning awakening. The study reports insomnia subtypes may be identified by examining personality traits of sufferers.
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A new machine learning algorithm is able to automatically able to distinguish between different patterns of progression in patients with a range of different dementias. The algorithm could enable to identify which treatments are most suited to individual patients.
Researchers report activating microglia may help reduce the imbalance between neuroprotection and neurotoxicity for neurodegenerative diseases.
A new study provides new clues for the links between aging and neurodegenerative diseases.