Gentamicin and G418, two aminoglycoside antibiotics, were effective at correcting genetic mutations associated with a specific form of frontotemporal dementia. The findings are promising for the treatment of frontotemporal dementia.
Researchers have identified one way in which an RNA binding protein may contribute to ALS.
Researchers report the C9ORF72 genetic mutation can lead to toxicity in neurons, causing 10 percent of all ALS cases and 10 percent of FTD cases.
The protein beta-arrestin-2 increases tau tangle accumulation in Alzheimer's disease and frontotemporal dementia but interfering with the removal of excess tau from the brain.
A new study may help shed light on the diversity of dementias linked to tau protein aggregation.
Immune cells appear to play a direct role in the development of ALS, a new study reports.
Researchers have identified the location of dysfunctional brain networks that lead to impaired sentence production and word-finding in primary progressive aphasia (PPA). PPA can occur in those with neurodegenerative diseases, such as frontotemporal dementia and Alzheimer's disease. Mapping the networks allows clinicians to apply non-invasive brain stimulation to potentially improve speech in those with PPA.