Engram cells encode details of memories as they are formed. These cells become reactivated when a memory is recalled. The process is controlled by remodeling of chromatin in the cells.
Imaging and manipulating engrams at the cellular level provides important insights into memory function.
After creating a memory in a context, engram cells encoding the memory in the hippocampus become more excitable when the context is repeated a short time later, researchers report.
Researchers propose a new theory of memory formation, reporting memory storage does not rely on the strengthening of connection between memory cells, but on the pattern of connections that form within the first few minutes of an event.
Researchers have identified a neural circuit that is critical for memory retrieval.
Long-term memories remain 'silent' for about 2 weeks before reaching a mature state, a new study reports.
Using optogenetics, researchers have successfully retrieved 'missing' memories in mouse models of Alzheimer's disease.
According to new research, stress induced depression may be overcome by inducing neurons which were activated during previous positive experiences.
