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CA3

·December 11, 2024·8 min read

Distinctive Neural Wiring Enhances Memory Storage

A new study has revealed distinct features of the human hippocampus, a brain region critical for memory storage and retrieval, challenging the assumption that it functions like a scaled-up mouse brain. By analyzing living brain tissue from epilepsy patients, researchers found that human hippocampal CA3 neurons exhibit sparse yet highly reliable connections, optimizing memory storage and retrieval. Unlike rodent brains, these unique wiring patterns enable the human brain to encode associative memories with greater efficiency.

Featured Neurology Neuroscience Open Neuroscience Articles

·May 20, 2022·5 min read

Brain Mechanism Tied to Age-Related Memory Loss Discovered

Researchers have identified a mechanism that occurs within the CA3 region of the hippocampus that appears to be responsible for a common type of age-related memory loss.

Featured Neuroscience

·February 15, 2021·5 min read

Peeking at the Pathfinding Strategies of the Hippocampus

Researchers observed hippocampal place cell changes in animal experiments of cue-poor and cue-rich spatial environments. The findings have implications for the treatment of brain disorders and the development of new AI technologies.

Featured Neuroscience Open Neuroscience Articles

·September 8, 2020·4 min read

What Makes Memories So Detailed and Enduring?

Researchers have identified a new mechanism of learning that stabilizes memory and reduces interference between different memories.

Electrophysiology Featured Neuroscience Psychology

·February 19, 2020·5 min read

Altered potassium levels in neurons may cause mood swings in bipolar disorder

Increased potassium currents were responsible for hyperactivity of CA3 neurons. When exposed to potassium channel blockers, the hyperactivity disappeared. However, when exposed to lithium, the drug not only reversed hyperactivity but reduced potassium currents at the same time. The findings strengthen the case that potassium currents play a role in bipolar disorder.

This shows a brain and some waves drawn beneath it

Featured Neurology Neuroscience Open Neuroscience Articles

·November 19, 2019·6 min read

Predicting Alzheimer’s disease-like memory loss before it strikes

Sharp-wave ripple activity in the brain may be an early biomarker for Alzheimer's disease before cognitive impairment begins.

Featured Neurology Neuroscience

·October 1, 2019·4 min read

Study provides possible explanation of how a seizure is able to spread through the brain

A new study implicated interneurons and pyramidal cells in the ability of a seizure to spread through the brain.

Autism Featured Neuroscience Open Neuroscience Articles

·June 4, 2019·4 min read

Exercise fine-tunes brain’s connections, eases autism spectrum disorder in mouse model

Participating in exercise improved synaptic pruning in mouse models of autism. The study also found microglia dependant synaptic pruning is impaired by maternal inflammation, which has been previously connected to the development of ASD.

A detailed drawing of the hippocampal formation is shown.

Electrophysiology Featured Neuroscience

·March 27, 2019·6 min read

Quick thinking? It’s all down to timing

A pairing of presynaptic and postsynaptic activity in a population of hippocampal neurons can reduce the required number of synaptic plasticity evoking events. When spikes occur within ten milliseconds of each other, synapses strengthen for up to four hours.

Featured Neuroscience Psychology

·February 25, 2019·3 min read

High Fructose Corn Syrup Consumption Linked to Bipolar Like Behaviors: Adolescent Rat Study

Researchers report adolescent rats exposed to high fructose corn syrup in their diets were more prone to experience symptoms associated with bipolar disorder.

Featured Neuroscience

·January 21, 2019·5 min read

Unexpected Link Between Feeding and Memory Brain Areas Discovered

A new study reveals how NCOR1/2 regulates memory involving a newly identified circuit between the lateral hypothalamus and hippocampus. Researchers believe the findings could have implications for future studies related to ASD and neurodegenerative diseases.

Featured Genetics Neuroscience Psychology

·January 8, 2019·4 min read

Childhood Stress Affects Behavior of Offspring: Mouse Study

Researchers report on the epigenetic effect of early life stress. In a new study, researchers reveal mice who experienced stress in the first few weeks of life showed deterioration in memory, learning and maternal behaviors. Behavioral changes were seen in their later offspring, regardless of sex.