Researchers have identified a new mechanism of learning that stabilizes memory and reduces interference between different memories. Read More
Increased potassium currents were responsible for hyperactivity of CA3 neurons. When exposed to potassium channel blockers, the hyperactivity disappeared. However, when exposed to lithium, the drug not only reversed hyperactivity but reduced potassium currents at the same time. The findings strengthen the case that potassium currents play a role in bipolar disorder. Read More
Sharp-wave ripple activity in the brain may be an early biomarker for Alzheimer's disease before cognitive impairment begins. Read More
A new study implicated interneurons and pyramidal cells in the ability of a seizure to spread through the brain. Read More
Participating in exercise improved synaptic pruning in mouse models of autism. The study also found microglia dependant synaptic pruning is impaired by maternal inflammation, which has been previously connected to the development of ASD. Read More
A pairing of presynaptic and postsynaptic activity in a population of hippocampal neurons can reduce the required number of synaptic plasticity evoking events. When spikes occur within ten milliseconds of each other, synapses strengthen for up to four hours. Read More
Researchers report adolescent rats exposed to high fructose corn syrup in their diets were more prone to experience symptoms associated with bipolar disorder. Read More
A new study reveals how NCOR1/2 regulates memory involving a newly identified circuit between the lateral hypothalamus and hippocampus. Researchers believe the findings could have implications for future studies related to ASD and neurodegenerative diseases. Read More
Researchers report on the epigenetic effect of early life stress. In a new study, researchers reveal mice who experienced stress in the first few weeks of life showed deterioration in memory, learning and maternal behaviors. Behavioral changes were seen in their later offspring, regardless of sex. Read More
A new study reports mother rats who received hormone replacement therapy responded worse to memory and spatial learning tasks than those who had not given birth. Researchers suggest a woman's reproductive history could impact how the brain responds to hormones later in life. Read More
Researchers have created a new model that may help explain how the brain stores memories of tangible events. The new model explains how neural activity in the hippocampus can help map space, time and context in episodic memories. Read More
Columbia University researchers reveal targeting a specific serotonin receptor can help to boost memory formation. The study reports targeting 5-HT4 receptors could help improve cognitive impairment. Read More
