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CA3

Electrophysiology Featured Neuroscience Psychology

·February 19, 2020·5 min read

Altered potassium levels in neurons may cause mood swings in bipolar disorder

Increased potassium currents were responsible for hyperactivity of CA3 neurons. When exposed to potassium channel blockers, the hyperactivity disappeared. However, when exposed to lithium, the drug not only reversed hyperactivity but reduced potassium currents at the same time. The findings strengthen the case that potassium currents play a role in bipolar disorder.

Image shows brain cells from a mouse cortex.

Featured Genetics Neurology Open Neuroscience Articles

·October 10, 2016·6 min read

Alzheimer’s Could be Treated With Gene Therapy: Mouse Study

Researchers report they have successfully prevented the development of Alzheimer's in mice by using gene therapy delivered by a virus to the brain.

Featured Genetics Neuroscience

·September 2, 2017·5 min read

Bone Derived Hormone Reverses Age Related Memory Loss: Mouse Study

Researchers report boosting levels of osteocalcin in the blood may help reverse age related memory loss in mice.

Featured Neuroscience Neuroscience Videos

·September 23, 2015·5 min read

Brain Circuit Critical in Forming Episodic Memory Identified

Researchers identify a neural circuit that connects the hippocampus and the entorhinal cortex, which is responsible for encoding episodic memory.

Featured Neurology Neuroscience Open Neuroscience Articles

·May 20, 2022·5 min read

Brain Mechanism Tied to Age-Related Memory Loss Discovered

Researchers have identified a mechanism that occurs within the CA3 region of the hippocampus that appears to be responsible for a common type of age-related memory loss.

Image shows a brain and marijuana leaves.

Featured Neuroscience Open Neuroscience Articles

·September 23, 2017·4 min read

Breaking Memory Circuits With Marijuana

New research reveals the dynamics of neural circuits under the influence of cannabinoids.

This is a drawing of the hippocampus with CA3, CA1 and the DG labeled.

Electrophysiology Featured Neuroscience

·March 30, 2015·3 min read

Building Block for Memory and Learning Identified

Researchers discover a key receptor which is responsible for activating opposing forms of plasticity in the hippocampus.

Image shows the CA1 area of the hippocampus highlighted in a mouse brain.

Featured Neuroscience

·January 18, 2016·5 min read

Cellular Diversity in the Hippocampus

Researchers have discovered an unexpected diversity within CA1 pyramidal neurons in the hippocampus.

Featured Genetics Neuroscience Psychology

·January 8, 2019·4 min read

Childhood Stress Affects Behavior of Offspring: Mouse Study

Researchers report on the epigenetic effect of early life stress. In a new study, researchers reveal mice who experienced stress in the first few weeks of life showed deterioration in memory, learning and maternal behaviors. Behavioral changes were seen in their later offspring, regardless of sex.

Image shows a diagram of the hippocampus.

Featured Neurology

·October 16, 2017·6 min read

Dietary Supplement Dampens Brain Hyperexcitability Seen in Epilepsy

Researchers were able to dampen hyperexcitability associated with seizure disorders in rodent models by inducing biochemical alterations with glucosamine, a dietary supplement.

The image shows a rat holding a hershey's kiss.

Featured Neuroscience

·February 27, 2013·3 min read

Discovery About Animal Memory Opens Doors to Research on Memory Impairment Diseases

A new study offers evidence of source memory in nonhuman animals.

Electrophysiology Featured Neuroscience

·October 8, 2012·2 min read

Discovery of Gatekeeper Nerve Cells Explains the Effect of Nicotine on Learning and Memory

Researchers discovered a new group of nerve cells that regulate processes of learning and memory. These cells act as gatekeepers and carry a receptor for nicotine, which can help explain our ability to remember and sort information. The newly discovered gatekeeper nerve cells, also called OLM-alpha2 cells, provide an explanation to how the flow of information is controlled in the hippocampus.

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