Researchers have identified a mechanism that occurs within the CA3 region of the hippocampus that appears to be responsible for a common type of age-related memory loss.
Researchers observed hippocampal place cell changes in animal experiments of cue-poor and cue-rich spatial environments. The findings have implications for the treatment of brain disorders and the development of new AI technologies.
Increased potassium currents were responsible for hyperactivity of CA3 neurons. When exposed to potassium channel blockers, the hyperactivity disappeared. However, when exposed to lithium, the drug not only reversed hyperactivity but reduced potassium currents at the same time. The findings strengthen the case that potassium currents play a role in bipolar disorder.
A new study implicated interneurons and pyramidal cells in the ability of a seizure to spread through the brain.
Participating in exercise improved synaptic pruning in mouse models of autism. The study also found microglia dependant synaptic pruning is impaired by maternal inflammation, which has been previously connected to the development of ASD.
A pairing of presynaptic and postsynaptic activity in a population of hippocampal neurons can reduce the required number of synaptic plasticity evoking events. When spikes occur within ten milliseconds of each other, synapses strengthen for up to four hours.
Researchers report adolescent rats exposed to high fructose corn syrup in their diets were more prone to experience symptoms associated with bipolar disorder.
A new study reveals how NCOR1/2 regulates memory involving a newly identified circuit between the lateral hypothalamus and hippocampus. Researchers believe the findings could have implications for future studies related to ASD and neurodegenerative diseases.
Researchers report on the epigenetic effect of early life stress. In a new study, researchers reveal mice who experienced stress in the first few weeks of life showed deterioration in memory, learning and maternal behaviors. Behavioral changes were seen in their later offspring, regardless of sex.
A new study reports mother rats who received hormone replacement therapy responded worse to memory and spatial learning tasks than those who had not given birth. Researchers suggest a woman's reproductive history could impact how the brain responds to hormones later in life.