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amyotrophic lateral sclerosis

This is a diagram of the brain and central nervous system.

·June 19, 2013·3 min read

Staging System in ALS Shows Potential Tracks of Disease Progression

Performing post-mortem staging of the brains and spinal cord tissue of patients with ALS, researchers discover the neurodegenerative disease could progress from one start point in the CNS to other regions of the brain and spinal cord.

The image shows the SOD1 in mice spinal cords. The caption best describes the image.

Featured Genetics Open Neuroscience Articles

·June 12, 2013·4 min read

Jammed Molecular Motors May Play Role in Development of ALS

A new study finds slowdowns in the transport and delivery of proteins, nutrients and signaling molecules within nerve cells could contribute to the development of ALS.

the image shows the difference between Hematopoietic and Stromal Stem Cells.

Featured Genetics

·May 28, 2013·3 min read

Engineered Stem Cell Advance Points Toward Treatment for ALS

Transplanting human stem cells into rat models with ALS improved survival and muscle function, according to a new study.

Featured Genetics

·May 27, 2013·5 min read

Researchers Identify Genetic Suspects in Sporadic Lou Gehrig’s Disease

Researchers have identified mutations in a number of genes which could be associated with the development of spontaneously occurring cases of ALS, a progressive and fatal neurodegenerative disease in which motor neurons gradually cease to function.

The illustration shows a cut away to the brain areas associated with Alzheimer's disease.

Featured Neurology

·May 10, 2013·3 min read

Cancer Drug Prevents Build-up of Toxic Brain Protein

Using a tiny dose of the leukemia drug nilotinib, researchers halt the accumulation of toxic proteins linked to Parkinson's diseases in the brains of mice.

Featured Neurology

·April 23, 2013·4 min read

ALS Trial Shows Novel Therapy is Safe

A new treatment for ALS, which uses a technique that turns off the mutated SOD1 gene, has passed an early phase clinical trial for safety.

The image shows a brain MRI of a patient with ALS.

Featured Genetics

·March 3, 2013·5 min read

Two New Genes Linked to ALS and Related Neurodegenerative Disorders

A new study ties mutations in two genes to the death of nerve cells in amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases.

The image shows a coronal view of a brain scan of a person with ALS.

Featured Neurology

·March 1, 2013·3 min read

Misplaced Molecules: New Insights into the Causes of Dementia

New research supports the idea that a malfunction of the TDP-43 protein plays a decisive role in the development of ALS and FTD.

The image shows a coronal MRI scan of a patient with ALS.

Featured Neurology

·February 12, 2013·3 min read

Novel Protein May Help Detect Lou Gehrig’s Disease and Dementia

Researchers discover an abnormal protein that accumulates in the brains of patients affected with ALS and frontotemporal dementia. The findings have uncovered a potentially new therapeutic target and biomarker that would allow clinicians to confirm diagnosis of the diseases.

Image shows brain slices with deposits of proteins associated with Alzheimer's and Parkinson's disease.

Featured Neurology

·February 5, 2013·3 min read

Study Confirms No Transmission of Alzheimer’s Proteins Between Humans

While evidence suggests pathological proteins linked to the onset and progression of neurodegenerative disorders are capable of spreading from cell-to-cell within the brains of affected individuals, new research shows no evidence to support concerns that these abnormal disease proteins are “infectious” or transmitted from animals to humans or from one person to another.

Featured Neuroscience

·January 21, 2013·3 min read

Researchers Turn One Form of Neuron into Another in the Brain

A new finding turns one of the basics of neurobiology on its head, demonstrating that it is possible to turn one type of already differentiated neuron into another within the brain.