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Myelin Continues to Grow Throughout Life

Summary: Researchers report myelin continues to form and restructure in the adult brain.

Source: Yale.

Myelin acts as insulation for millions of brain cells, allowing for swift and efficient transmission of signals across brain regions. Despite its crucial role, little is known about how stable this structure is in the adult brain and what impact aging has on its maintenance.

Yale neurologists Robert Hill, Alice Li, and Jaime Grutzendler devised techniques to track and precisely image myelin throughout the lifetime of the mouse. They discovered that myelin continues to form and restructure in the adult brain — indicating the potential for lifelong change. They also learned that during aging, myelin begins to deteriorate and myelin debris accumulate over time.

“Myelin is not static in the adult brain and may play an underappreciated role in brain plasticity, a role that is likely to be disrupted as we age,” Hill said.

myelin

Myelin, the sheathing which protects connections between brain cells, continues to form throughout life, as seen here in light blue. NeuroscienceNews.com image is credited to the researchers.

About this neuroscience research article

Source: Bill Hathaway – Yale
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to the researchers.
Original Research: Abstract in Nature Neuroscience.
doi:10.1038/s41593-018-0120-6

Cite This NeuroscienceNews.com Article
Yale “Myelin Continues to Grow Throughout Life.” NeuroscienceNews. NeuroscienceNews, 20 March 2018.
<http://neurosciencenews.com/myelin-regrowth-8679/>.
Yale (2018, March 20). Myelin Continues to Grow Throughout Life. NeuroscienceNews. Retrieved March 20, 2018 from http://neurosciencenews.com/myelin-regrowth-8679/
Yale “Myelin Continues to Grow Throughout Life.” http://neurosciencenews.com/myelin-regrowth-8679/ (accessed March 20, 2018).

Abstract

Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain

Axonal myelin increases neural processing speed and efficiency. It is unknown whether patterns of myelin distribution are fixed or whether myelinating oligodendrocytes are continually generated in adulthood and maintain the capacity for structural remodeling. Using high-resolution, intravital label-free and fluorescence optical imaging in mouse cortex, we demonstrate lifelong oligodendrocyte generation occurring in parallel with structural plasticity of individual myelin internodes. Continuous internode formation occurred on both partially myelinated and unmyelinated axons, and the total myelin coverage along individual axons progressed up to two years of age. After peak myelination, gradual oligodendrocyte death and myelin degeneration in aging were associated with pronounced internode loss and myelin debris accumulation within microglia. Thus, cortical myelin remodeling is protracted throughout life, potentially playing critical roles in neuronal network homeostasis. The gradual loss of internodes and myelin degeneration in aging could contribute significantly to brain pathogenesis.

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