Gut microbes that metabolize tryptophan secrete indoles that stimulate the development of new neurons in the adult brain.
TET1, a newly identified molecule appears to play a key role in myelin repair. The findings could have implications for the treatment of a range of neurodegenerative diseases, including multiple sclerosis.
Mouse study reveals intermittent fasting improves long-term memory retention and promotes hippocampal neurogenesis. The findings could help to slow cognitive decline in older adults.
MicroRNA-132 regulates neurogenesis in the hippocampus, according to both mouse and human tissue studies. Restoring levels of microRNA-132 in mouse models of Alzheimer's disease reduces neurogenetic deficits and restores cognitive abilities, researchers say.
At the site of injury, nerves release a protein called CXCL12 which attracts growing nerve fibers and keeps them trapped in place. This prevents the nerve fibers from growing in the correct direction to bridge the injury site.
Following injury or damage, insulin plays a key role in the maturation and regeneration of immature olfactory sensory neurons.
PINK1, a gene associated with Parkinson's disease, is not just responsible for the premature death of dopaminergic neurons, it also plays a key role in the neurogenesis of dopamine neurons throughout life.
Study identifies 40 genes in mice that actively suppress axon regeneration in the central nervous system.
A newly developed biodegradable microcapsule that delivers nerve growth factor guides the development of hippocampal neurons in in-vitro experiments.