The genetic signature of memory
Cortical and subcortical memory regions exhibit distinct genetic signatures that reflect potential differences in health and disease.... Read More...
neurogenesis
Bacteria in the gut may alter aging process
Transplanting gut microbiota from older mice to younger germ-free mice increased hippocampal neurogenesis and intestinal growth.... Read More...
Creation of new brain cells plays an underappreciated role in Alzheimer’s disease
Microglia may play a significant role in disrupting neurogenesis in those with Alzheimer's disease. When mice were given drugs which caused microglial cells to die, neurogenesis returned to normal.... Read More...
Machine learning algorithm can’t distinguish these lab mini-brains from preemie babies
Machine learning is unable to tell the difference in brain activity between a lab-grown mini-brain and that of a preterm infant who has reached full-term.... Read More...
Signal blocks stem cell division in the geriatric brain
A gene regulated called Id4 appears to be a key component in controlling stem cell proliferation. ... Read More...
Alzheimer’s drug reverses brain damage from adolescent alcohol exposure
Donepezil, a drug routinely administered to slow cognitive decline in Alzheimer's disease, shows promise in treating damage caused to the brain by adolescent alcohol exposure. The drug reverses neuroinflammation and neuron damage in rats exposed to alcohol during adolescence. ... Read More...
Scientists reverse aging process in rat brain stem cells
Removing Piezo1 from the surface of aged brain stem cells caused the cells to become rejuvenated and regain their normal regenerative function.... Read More...
How chronic stress causes brain damage
Chronic stress causes autophagy in adult hippocampal neural stem cells. This results in a decline of hippocampal neurogenesis. Cognitive deficits and mood disorders that arise as a result of chronic stress are a result of autophagic death of hippocampal neural stem cells.... Read More...
To become, or not to become… a neuron
Bcl6 acts as a driver of neurogenic transition by directly silencing a selection of genes that belong to multiple extrinsic pathways promoting self-renewal. Bcl6 is only expressed in specific subsets of neurons and progenitor cells during brain development.... Read More...
Exosomes may hold the answer to treating and diagnosing developmental brain disorders
Exosomes carry signaling information required to regulate neural circuit development.... Read More...
Reducing seizures by removing newborn neurons
Removing new neurons generates as a result of neurogenesis following brain injury reduced seizure activity in mouse models of mesial temporal lobe epilepsy.... Read More...
First step to induce self-repair in the central nervous system
Severed axonal segments signal to Schwann cells to begin actin sphere formation and axon disintegration. If the process is disrupted, axon disintegration is slowed and axon fragments impair nerve regeneration.... Read More...