Newly identified cellular trash removal program helps create new neurons
Vimentin, a cellular filament, helps neural stem cells to clear damaged and clumped proteins, assisting in neurogenesis.... Read More...
neurogenesis
Gene associated with autism also controls growth of the embryonic brain
In normally developing mice, the autism-associated Foxp1 gene was activated earlier than previously believed. This occurred during the period when apical radial glia was beginning to expand in numbers and generate a subset of neurons found deep in the developing brain. Mice lacking Foxp1 had fewer apical radial glia at the early stages of brain development.... Read More...
Brain tissue stiffness is crucial for neurogenesis
Researchers define the proteome of neural stem cell niches and the entire set of expressed proteins. The findings shed light on key regulators of neurogenesis.... Read More...
Synthetic nerve conduit bridges the gap in arm nerve repair
A new synthetic conduit can bridge large nerve gaps by guiding the regrowth of neurons. When implanted into the arms of macaques with nerve defects in their arms, the conduit boosted neurogenesis and the nerve's ability to conduct signals for a year.... Read More...
A new role for neurogenesis
Dentate gyrus neurogenesis acts to replace lost neurons and restore function following massive neuron loss. ... Read More...
Rejuvenating the brain: More stem cells improve learning and memory of old mice
Critical aspects of hippocampal function can be reversed in old age, or compensated for throughout life, with the help of neural stem cells.... Read More...
High fat diet impairs new neuron creation in female mice
Female mice exposed to a high-fat diet have limited hippocampal neurogenesis. The findings may explain why women are at higher risk of developing dementia than men.... Read More...
The genetic signature of memory
Cortical and subcortical memory regions exhibit distinct genetic signatures that reflect potential differences in health and disease.... Read More...
Bacteria in the gut may alter aging process
Transplanting gut microbiota from older mice to younger germ-free mice increased hippocampal neurogenesis and intestinal growth.... Read More...
Creation of new brain cells plays an underappreciated role in Alzheimer’s disease
Microglia may play a significant role in disrupting neurogenesis in those with Alzheimer's disease. When mice were given drugs which caused microglial cells to die, neurogenesis returned to normal.... Read More...
Machine learning algorithm can’t distinguish these lab mini-brains from preemie babies
Machine learning is unable to tell the difference in brain activity between a lab-grown mini-brain and that of a preterm infant who has reached full-term.... Read More...
Signal blocks stem cell division in the geriatric brain
A gene regulated called Id4 appears to be a key component in controlling stem cell proliferation. ... Read More...