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neurogenesis

Featured Genetics Neurology Neuroscience

·April 30, 2024·4 min read

Enhancing Neurogenesis for Parkinson’s Treatment

Researchers have pioneered a method to enhance the generation of dopaminergic neurons, crucial for Parkinson’s disease treatment, by targeting specific receptors within the Wnt signaling pathway. Using synthetic antibodies, the team successfully directed stem cell differentiation in the midbrain to produce these key neurons, which are instrumental in brain health and depleted in Parkinson’s patients.

Featured Neurology Neuroscience

·April 19, 2024·4 min read

Blessed Thistle Enhances Nerve Regeneration

Cnicin, a compound derived from the plant Blessed Thistle, significantly enhances nerve regeneration. The study shows that Cnicin can accelerate the growth of axons, the long fibers of nerve cells, which is crucial for the recovery of nerve function after injury.

Featured Genetics Neurology Neuroscience

·April 5, 2024·4 min read

Powering Brain Repair: Mitochondria Key to Neurogenesis

Researchers made a groundbreaking discovery about the maturation process of adult-born neurons in the brain, highlighting the critical role of mitochondrial fusion in these cells. Their study shows that as neurons develop, their mitochondria undergo dynamic changes that are crucial for the neurons' ability to form and refine connections, supporting synaptic plasticity in the adult hippocampus.

Featured Neuroscience

·October 6, 2023·6 min read

Thalamus Plays a Pivotal Role in Adult Brain Plasticity

Researchers spotlight the thalamus, typically regarded merely as a relay station, as a pivotal entity in adult brain plasticity. Contrasting prior beliefs focusing largely on the cortex, the thalamus demonstrates a significant role in adapting sensory and motor information, as illuminated through mouse models in vision studies.

Featured Neuroscience

·September 7, 2023·8 min read

Could Neurogenesis and Navigating Change Be Key to Cognitive Flexibility?

Researchers are closing in on the relationship between cognitive adaptability and adult neurogenesis. They developed a novel animal model to test cognitive flexibility by adding layers of complexity to a maze challenge.

Featured Neurology Neuroscience

·July 21, 2023·6 min read

Rejuvenating the Brain: Healthy Cells Replace Diseased Ones

A promising study reveals transplanted healthy glial cells can outcompete and replace diseased or aged brain cells, potentially restoring normal brain function. This breakthrough suggests a broad potential for the treatment of neurodegenerative diseases, such as Huntington's disease, ALS, and some genetic schizophrenia.

Featured Neurology Neuroscience

·June 16, 2023·5 min read

Neurodevelopment and Dementia: Could Prolonged Human Neurogenesis Lead to Alzheimer’s?

Researchers delved into the prolonged neurogenesis process in humans, investigating the amyloid precursor protein (APP). APP's fragmentation leads to amyloid peptides associated with Alzheimer's disease.

Featured Neuroscience

·May 25, 2023·5 min read

Running Rewires the Aging Brain: Exercise Protects Memory Function

Physical activity, particularly running, has been found to rewire aging brains, helping to preserve memory functions. Researchers revealed long-term running keeps older neurons wired, potentially preventing age-related memory loss and neurodegeneration. This effect is believed to be especially beneficial for neurons born during early adulthood, whose circuitry is modifiable through midlife exercise. The findings underscore the importance of regular physical activity in maintaining cognitive health as we age.

Featured Genetics Neuroscience

·April 21, 2023·4 min read

Key Protein of Hippocampal Neurogenesis Discovered

The protein Yap1 plays a key role in the generation of new neurons in the hippocampus. However, tight regulation of Yap1 activity is essential as dysregulation causes the disruption of tissue seen in glioblastoma brain cancer.

Featured Neurology Neuroscience

·April 11, 2023·4 min read

Scientists Enhance New Neurons to Restore Memory and Elevate Mood in Alzheimer’s Disease

Stimulating the Supramammilary nucleus in the hypothalamus enhanced adult-born neurons in the hippocampus of mouse models of Alzheimer's disease. These modified adult-born neurons restored both cognitive impairments and mood-related disorders associated with Alzheimer's in the mice.

Featured Neurology Neuroscience

·April 8, 2023·6 min read

How Do We Know if Our Brain Is Capable of Repairing Itself?

A new study examines the regenerative potential of the human brain in aging and neurological diseases, which could provide an alternative to conventional strategies for enhancing or restoring brain function. Recent single-cell transcriptomic studies in the adult human hippocampus yielded conflicting results, and the researchers found that the design, analysis, and interpretation of these studies in the adult human hippocampus can be confounded by specific issues that require particular attention and would greatly profit from an open discussion in the field.