Study reveals an association between signal detection theory, brain activation patterns, and subjective state fatigue. In those with multiple sclerosis, greater effects of fatigue were seen.
Researchers discovered oligodendrocytes, myelin-producing cells within the central nervous system, become established in the brain during early fetal development.
Study reports oligodendrocytes in the brain are distinct from oligodendrocytes in the central nervous system due to their metabolic processes. The findings may shed new light on neurological and autoimmune dysfunction in multiple sclerosis and other neurodegenerative disorders.
A small-molecule metabolite produced by gut bacteria in mice, can travel to the brain and alter brain cell function, inducing anxiety behaviors.
Around 25% of patients with multiple sclerosis have blood antibodies that bind to the Epstein-Barr virus and EBNA1, a protein made in the brain and spinal cord. Researchers say this is the first study to definitely show that the Epstein-Barr virus can cause multiple sclerosis in some patients.
Cholesterol synthesis in nerve cells ensures the replenishment of newly myelin-forming cells. The findings could provide new treatment options for the treatment of disorders associated with myelin loss, such as multiple sclerosis.
Analyzing the gene activity of 66,000 cells from human brain tissue, researchers generated a comprehensive map of cell types associated with brain lesions in multiple sclerosis, and their gene expression patterns and interactions.