Cholesterol synthesis in nerve cells ensures the replenishment of newly myelin-forming cells. The findings could provide new treatment options for the treatment of disorders associated with myelin loss, such as multiple sclerosis.
Analyzing the gene activity of 66,000 cells from human brain tissue, researchers generated a comprehensive map of cell types associated with brain lesions in multiple sclerosis, and their gene expression patterns and interactions.
HIV infection prevents myelin-associated oligodendrocytes from maturing, this, in turn, hampers white matter production in the brain.
Lower serum levels of the sugar metabolite GlcNAc was associated with progressive disability and neurodegeneration in patients with multiple sclerosis.
Researchers shed new light on how remylination fails in multiple sclerosis. The study reports a drug, currently being studied as a cancer therapy, can alter the key signaling cascades that result in demylination associated with MS.
Cells that drive myelin repair become less efficient due to aging. Myelin loss results in cognitive decline and is central to a number of neurodegenerative diseases.
Some of the T cell epitopes targeting myelin in monkeys were the same as those found in humans. Researchers say linking these specific cells opens the doors to developing antiviral therapies that could be useful to treat newly diagnosed cases of MS in humans.