Latest

microglia

·August 14, 2026·4 min read

Youth Protein TIMP2 Restores Immune Function in the Aging Brain

Researchers discovered that the youth-associated protein TIMP2 restores healthy immune function in the aging brain by rejuvenating microglia.

Featured Neuroscience

·August 6, 2026·11 min read

Peripheral Blood Cells Replenish Aging Human Microglia

Peripheral blood-derived immune cells cross into the aging human brain and transform into functional microglia.

Featured Neuroscience

·July 31, 2026·7 min read

Ketamine Reshapes Neural Networks and Neuroplasticity

Ketamine triggers a corticosterone-FKBP51 signaling pathway in female mice that prompts microglia to clear extracellular matrix and enhance synaptic plasticity, an immune-driven mechanism absent in males.

Featured Neuroscience

·July 27, 2026·6 min read

SRGAP2 Slows Human Microglial Maturation

Human-specific duplicates of the SRGAP2 gene slow microglial maturation to four to eight years.

Featured Neurology Neuroscience

·July 9, 2026·10 min read

Loss of TDP-43 Strips Microglia of Their Brain-Cleaning Power

The TDP-43 protein is an essential regulator of microglial housekeeping in the developing brain.

Featured Genetics Neurology Neuroscience

·June 7, 2026·9 min read

Microglial State Transitions Dictate Alzheimer’s

A new study identifies a critical microglial state transition that determines whether pathology progresses toward clinical dementia.

Featured Neurology Neuroscience

·May 22, 2026·10 min read

Microglia Overloaded with Fat Linked to Rapid MS

Why do some multiple sclerosis patients deteriorate rapidly while others experience mild symptoms for decades? A post-mortem neuro-audit reveals that severe MS progression is linked to "foamy microglia", brain immune cells pathologically overloaded with fat droplets.

Featured Neuroscience Psychology

·May 14, 2026·6 min read

Brain Immune Cells Drive Compulsive Behavior

Is anxiety an immune response? New research reveals that Hoxb8 microglia, specialized immune cells in the brain, use calcium signaling to switch anxiety and grooming behaviors on and off.

Featured Neurology Neuroscience

·May 12, 2026·7 min read

Slowing Parkinson’s by Blocking a Key Protein

A new study found that GPNMB, released by the brain's immune cells, accelerates the spread of toxic alpha-synuclein. By using monoclonal antibodies to block GPNMB, the team successfully interrupted the cycle of neurodegeneration in preclinical models. This discovery provides a new therapeutic target that could finally slow the progression of Parkinson’s at its earliest stages.

This shows an older woman sleeping and microglia.

Featured Neurology Neuroscience

·May 12, 2026·6 min read

Targeting Brain “Clean-up” Cells to Fight Dementia

Researchers discovered that dysregulated circadian rhythms cause microglia, the brain’s immune cells, to become "stress-primed" and malfunction. This state prevents them from clearing amyloid plaques, accelerating dementia risk. Now, using DARI seedling grants, Souza is testing a stem-cell-derived "EV therapy" designed to keep these cells healthy and prevent neuroinflammation.

Brain Cancer Featured Neurology Neuroscience

·April 21, 2026·7 min read

Alzheimer’s Brains Share a Genetic Signature with Some Cancers

A study finds that Alzheimer’s is driven by cancer-like mutations in the brain's immune cells, which may enter from the blood and trigger lethal brain inflammation.

Featured Genetics Neurology Neuroscience

·April 7, 2026·6 min read

Single Immune Switch Drives Both Arthritis and Alzheimer’s

Researchers identify TREM-1 as a potent amplifier of the innate immune system. The review suggests that targeting this receptor could provide new treatments for sepsis, arthritis, and Alzheimer’s.

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microglia

Youth Protein TIMP2 Restores Immune Function in the Aging Brain

Peripheral Blood Cells Replenish Aging Human Microglia

Ketamine Reshapes Neural Networks and Neuroplasticity

SRGAP2 Slows Human Microglial Maturation

Loss of TDP-43 Strips Microglia of Their Brain-Cleaning Power

Microglial State Transitions Dictate Alzheimer’s

Microglia Overloaded with Fat Linked to Rapid MS

Brain Immune Cells Drive Compulsive Behavior

Slowing Parkinson’s by Blocking a Key Protein

Targeting Brain “Clean-up” Cells to Fight Dementia

Alzheimer’s Brains Share a Genetic Signature with Some Cancers

Single Immune Switch Drives Both Arthritis and Alzheimer’s

How Severe Illness During Pregnancy Alters Fetal Brain Development

Aging Brains Maintain Robust Language Networks Despite Cognitive Decline

Youth Protein TIMP2 Restores Immune Function in the Aging Brain

Shame, Stigma, and Culture Prevent Male Domestic Violence Survivors From Seeking Help

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