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microglia

Featured Neuroscience Visual Neuroscience

·July 24, 2025·4 min read

Immune Cells Ignore Retinal Damage While Microglia Step In

Unlike most tissues, the retina doesn’t summon neutrophils—the body’s typical first responders—when injured. Instead, microglia, the brain’s resident immune cells, handle photoreceptor damage without calling for backup.

This shows a person on a treadmill and neurons.

Featured Genetics Neurology Neuroscience

·June 13, 2025·5 min read

Exercise Rewires Alzheimer’s-Affected Brain Cells

Using cutting-edge RNA sequencing, researchers mapped how exercise affects specific brain cell types in a model of Alzheimer’s disease. They found that physical activity alters gene activity in microglia and a newly identified type of astrocyte linked to blood vessels, which may protect memory.

Brain Cancer Featured Neurology Neuroscience

·May 13, 2025·7 min read

CAR-T Brain Fog Mirrors Chemo and COVID

Patients receiving CAR-T cell therapy often report brain fog, and new research shows this cognitive impairment stems from the therapy itself, not just the cancer or other treatments. A mouse study revealed that CAR-T-induced immune responses activate brain microglia, triggering inflammation that damages myelin-producing cells, reducing signal efficiency in the brain.

Featured Neuroscience Psychology

·May 4, 2025·12 min read

Why Alcohol Hits Women Harder

Alcohol use among women has surged to match men’s rates, but women face far greater health risks even at lower consumption levels. A growing body of research is uncovering key neurobiological sex differences that influence why and how women drink, with stress being a more prominent motivator for women.

Featured Genetics Neurology Neuroscience

·April 22, 2025·5 min read

Microglia Reprogrammed to Deliver Precision Alzheimer’s Therapies

Researchers have developed engineered human microglia that detect disease-related brain changes and release therapeutic proteins precisely where needed. Using CRISPR technology, the team programmed these cells to secrete an enzyme that breaks down beta-amyloid plaques only in affected areas.

Featured Genetics Neurology Neuroscience

·April 10, 2025·5 min read

Blocking Tim-3 Boosts Microglia in Alzheimer’s

New research reveals that the immune checkpoint molecule Tim-3 plays a critical role in how microglia, the brain’s immune cells, respond to Alzheimer’s disease. While Tim-3 normally helps maintain brain homeostasis, it can also inhibit microglia from clearing harmful plaques that accumulate in Alzheimer’s.

Featured Neuroscience Psychology

·March 3, 2025·4 min read

Brain Changes From Early-Life Stress May Be Reversible

A new study reveals how prenatal infections followed by early-life stress—known as "two-hit stress"—can lead to brain dysfunction and psychiatric-like behaviors. Researchers found that affected mice showed abnormal cerebellar activity, increased microglial turnover, and impaired brain-wide connectivity.

Featured Neuroscience

·January 21, 2025·5 min read

Microglia Act Differently in Male and Female Brains

Microglia, the brain’s immune cells, play vital roles in clearing toxins and maintaining neuronal health but can also contribute to neurodegenerative diseases if overactive. New research reveals sex-based differences in how adult male and female microglia respond to the enzyme inhibitor PLX3397, a common tool in microglial research. While male microglia showed the expected depletion, female microglia employed alternative signaling pathways, leading to increased survival.

Featured Neurology Neuroscience

·October 17, 2024·4 min read

Microglia Found to Protect Neurons Post-Spinal Cord Injury

Researchers discovered a neuroprotective mechanism in spinal cord injury (SCI) involving microglia, the brain’s immune cells, which could provide new therapeutic targets. Using advanced in vivo imaging, the team revealed that microglia form protective wraps around injured axons, preventing further damage. This interaction, regulated by P2Y12 receptors and sodium channels, sheds light on neuron-glia communication after injury. The study's insights into spinal cord protection could eventually lead to new treatments for SCI and related neurological diseases.

Featured Neurology Neuroscience

·June 12, 2024·4 min read

New Target for Spinal Cord Injury Treatment Identified

Researchers discovered a druggable target that could prevent autonomic dysfunction after spinal cord injury. The research found that microglia cells control abnormal nerve growth and autonomic reflexes. By depleting microglia in a mouse model, researchers prevented life-threatening complications. This finding could lead to new therapies for spinal cord injuries and other neurological conditions.

This shows a doctor looking at brain scans.

Featured Neurology Neuroscience

·April 3, 2024·6 min read

Immunotherapy Shows Promise as Alzheimer’s Treatment

Researchers unveiled a novel approach to combat Alzheimer’s disease by activating microglia, the brain's immune cells, to devour amyloid beta plaques, a hallmark of the condition. This study highlights the potential of using immunotherapy to not only tackle Alzheimer’s but also other neurodegenerative diseases characterized by harmful protein accumulations.

Featured Neuroscience

·March 20, 2024·4 min read

Microglia Are Key Players in Awakening the Brain Post-Anesthesia

Microglia, the central nervous system's immune cells, are crucial in helping the brain recover from anesthesia. By interacting directly with brain circuits and inhibitory synapses, microglia work to counteract sedation effects, offering new insights into managing post-anesthesia delirium and hyperactivity.

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microglia

Immune Cells Ignore Retinal Damage While Microglia Step In

Exercise Rewires Alzheimer’s-Affected Brain Cells

CAR-T Brain Fog Mirrors Chemo and COVID

Why Alcohol Hits Women Harder

Microglia Reprogrammed to Deliver Precision Alzheimer’s Therapies

Blocking Tim-3 Boosts Microglia in Alzheimer’s

Brain Changes From Early-Life Stress May Be Reversible

Microglia Act Differently in Male and Female Brains

Microglia Found to Protect Neurons Post-Spinal Cord Injury

New Target for Spinal Cord Injury Treatment Identified

Immunotherapy Shows Promise as Alzheimer’s Treatment

Microglia Are Key Players in Awakening the Brain Post-Anesthesia

Key Brain Circuit Linked to Teen Anxiety Identified

Early Blindness Tunes Pitch Perception

LSD Microdosing Enhances Sustained Attention in Women

Cannabis Destroys Sleep Quality

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