Latest

microglia

·May 11, 2023·7 min read

Human Brain Organoids Reveal How Microglia Develop and Function

Researchers have developed human brain organoids that contain microglia, the immune cells of the brain. These organoids allow researchers to study how microglia develop and function in a more realistic setting than previous models. The researchers found that microglia are influenced by the environment in which they develop, and that they play a role in both development and disease. Their findings could lead to new treatments for neurological disorders.

This shows the outline of a head and a brain

Featured Neurology Neuroscience Open Neuroscience Articles

·March 8, 2023·3 min read

Fresh Understanding of Aging in the Brain Offers Hope for Treating Neurological Diseases

As the brain ages, microglia adopt dysfunctional states that increase the risk of developing neurodegenerative diseases such as Alzheimer's disease.

Featured Genetics Neurology Neuroscience

·January 30, 2023·5 min read

How Our Brains Turn Into Smarter Disease Fighters

CRISPR gene editing created the G795A amino acid which was introduced to microglia derived from human stem cells. Researchers were able to transplant the donor microglia immune cells into humanized rodent models while administering an FDA-approved cancer drug called pexidartinib. The inclusion of the amino acid cause the donated microglia to thrive and resist the drug, while the host microglia died. The findings open the door for new methods of using microglia to treat a range of neurodegenerative disorders.

Featured Neurology Neuroscience Pain

·January 30, 2023·5 min read

Calcium Channels Regulate Neuroinflammation and Neuropathic Pain

The Orai1 class of calcium channels regulates sex differences in the functioning of immune cells associated with neuroinflammation and neuropathic pain.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·January 25, 2023·4 min read

Drug That Targets Tauopathies in Mice Reveals Sex Differences in Response

Exposure to drugs that target tauopathies extended survival, reduced neurodegenerative biomarkers, and functionally reduced aberrant behaviors in female mice, but not in males.

Featured Neuroscience Open Neuroscience Articles

·January 17, 2023·3 min read

High Fat Diet Activates Early Inflammation in Mouse Brains, Supports Link to Neurological Disease

High-fat diets promote early inflammatory responses in the brain via an immune pathway associated with diabetes and neurodegenerative diseases. The findings suggest a link between metabolic dysfunction and cognitive impairment.

This shows a diagram of the anatomical structure

Featured Neuroscience

·January 6, 2023·5 min read

Newly Discovered Anatomy Shields and Monitors Brain

Researchers have discovered a previously unidentified component of brain anatomy that acts as both a protective barrier and a platform by which immune cells monitor the brain for signs of inflammation and infection.

Featured Genetics Neurology Neuroscience

·January 5, 2023·3 min read

Alzheimer’s Disease Researchers Study Gene Associated With the Brain’s Immune Cells

Reduction of the INPP5D gene variant found in the brain's microglia could help to diminish the risk of late-onset Alzheimer's disease.

Featured Neurology Neuroscience Neuroscience Videos

·December 10, 2022·6 min read

Harnessing the Brain’s Immune Cells to Stave off Alzheimer’s and Other Neurodegenerative Diseases

Researchers have identified a protein that could be leveraged to help microglia in the brain stave off Alzheimer's and other neurodegenerative diseases.

Featured Neuroscience

·November 29, 2022·3 min read

Key Factors Identified for Regeneration of Brain Tissue

Researchers have identified two proteins that prevent the formation of scars in the brain and help promote the regeneration of new neural tissue.

Featured Neurology Neuroscience

·November 29, 2022·3 min read

The Brain’s Immune Cells Can Be Triggered to Slow Down Alzheimer’s Disease

Activating TREM2 on microglia in the brains of those with Alzheimer's could help slow down the progression of the neurodegenerative disease.

Featured Neurology Neuroscience

·November 3, 2022·4 min read

The Brain’s Immune Cell Response in Alzheimer’s Disease

Deletion of the neurodegenerative disease associated microglial gene CX3CR1 aggravated the disease state and increased the accumulation of plaques in the brains of mouse models of Alzheimer's disease. Deficiencies of the gene also impaired the movement of microglia toward the plaques.

1 2 3 4 5 6 … 25