Stimulating activation of microglia may help eliminate Alzheimer's associated plaques, thus helping to prevent the progression of the neurodegenerative disease. Read More
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Visceral fat impairs memory via proinflammatory interleukin-1 beta mediated microglia activation in the hippocampus. Read More
Microglia initially protects the blood-brain barrier from damage due to systemic inflammation. However, microglia can alter their behavior and increase the permeability of the blood-brain barrier, thus damaging it. Read More
By inhibiting a particular receptor microglia use to survive, researchers reduced neuroinflammation and prompted recovery following traumatic brain injury in mouse models. Read More
Altering microglia in rats helped enhance their performance in memory tasks by up to 50%. The findings could help to develop new therapies that enhance memory function and prevent cognitive decline in humans. Read More
Microglia, key immune cells in the brain, may play a significant role in memory retention. Read More
Microglia can interfere with macrophages, preventing the movement of these blood immune cells to injury sites. The findings could help in the development of new treatments for multiple sclerosis, Alzheimer's disease, and spinal cord injury. Read More
Microbiota-derived short-chain fatty acids (SCFA) modulate stroke recovery. The effect was mediated by circulating lymphocytes on microglia activation. The study reports SCFAs could be a potential therapeutic to improve post-stroke recovery. Read More
Female mice exposed to a high-fat diet have limited hippocampal neurogenesis. The findings may explain why women are at higher risk of developing dementia than men. Read More
White blood cells in the brain are regulated by the CD33 protein. CD33 decreases the likelihood that a person will develop Alzheimer's disease. Read More
The NLPR3 inflammasome and the inflammatory response it triggers play a critical role in the emergence of tau pathology. Read More
Mice bred to be germ-free, and those treated with antibiotics showed a significant reduction in the ability to learn that a threatening danger was no longer present. Sequencing the RNA of microglia in the brains of the animals reveals altered gene expression in the immune cells, which play a role in remodeling how neurons connect during the learning process. Restoring the gut microbiota reverse the learning problems. Read More
