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microglia

·September 19, 2023·5 min read

Aging in the Brain: Microglial Changes Differ Between Sexes

Researchers delved into how microglial cells in the brain age and their link to brain dysfunction. Their study, using male and female mice, found surprising sex-based distinctions in microglial aging.

Featured Neuroscience

·July 19, 2023·6 min read

Motherly Love? Immune System Changes May Play a Role

Changes in the immune system during pregnancy, specifically the decrease of immune cells known as microglia, may contribute to the onset of maternal behavior. Depletion of microglia in female rats, who typically dislike being around offspring, led to accelerated care for newborn rats placed in their cages.

Featured Neuroscience Psychology

·June 5, 2023·6 min read

Microglia’s Role in Controlling Anxiety and OCD

A new study reveals how microglia can regulate anxiety and obsessive-compulsive spectrum disorder (OCSD) behaviors. Traditionally overlooked in favor of neurons, specific microglia populations were found to both stimulate and suppress these behaviors, thus acting as both a "brake" and "accelerator".

Featured Neuroscience

·May 30, 2023·4 min read

Understanding Microglia’s Dual Roles Could Aid Brain Protection

Researchers made a significant discovery regarding microglia, the immune cells of the central nervous system, and their role in neurodegenerative diseases. They investigated how these cells respond to injury and their change in behavior under specific conditions.

Featured Neuroscience Psychology

·May 22, 2023·5 min read

Microglia Less Active in Those With Depression

Researchers have uncovered a crucial link between depression and the immune system. A new study reveals microglial cells, a type of immune cell in the brain, are less active in individuals with depression.

Featured Neuroscience

·May 15, 2023·4 min read

Unique Microglia Subset Crucial for Cognitive Functioning

A new study discovered not all microglia are the same, challenging existing beliefs. A unique subset of these cells, the ARG1+microglia, important for proper cognitive functions, were identified in mice, with evidence suggesting a similar subset exists in humans.

Featured Neuroscience

·May 11, 2023·7 min read

Human Brain Organoids Reveal How Microglia Develop and Function

Researchers have developed human brain organoids that contain microglia, the immune cells of the brain. These organoids allow researchers to study how microglia develop and function in a more realistic setting than previous models. The researchers found that microglia are influenced by the environment in which they develop, and that they play a role in both development and disease. Their findings could lead to new treatments for neurological disorders.

This shows the outline of a head and a brain

Featured Neurology Neuroscience Open Neuroscience Articles

·March 8, 2023·3 min read

Fresh Understanding of Aging in the Brain Offers Hope for Treating Neurological Diseases

As the brain ages, microglia adopt dysfunctional states that increase the risk of developing neurodegenerative diseases such as Alzheimer's disease.

Featured Genetics Neurology Neuroscience

·January 30, 2023·5 min read

How Our Brains Turn Into Smarter Disease Fighters

CRISPR gene editing created the G795A amino acid which was introduced to microglia derived from human stem cells. Researchers were able to transplant the donor microglia immune cells into humanized rodent models while administering an FDA-approved cancer drug called pexidartinib. The inclusion of the amino acid cause the donated microglia to thrive and resist the drug, while the host microglia died. The findings open the door for new methods of using microglia to treat a range of neurodegenerative disorders.

Featured Neurology Neuroscience Pain

·January 30, 2023·5 min read

Calcium Channels Regulate Neuroinflammation and Neuropathic Pain

The Orai1 class of calcium channels regulates sex differences in the functioning of immune cells associated with neuroinflammation and neuropathic pain.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·January 25, 2023·4 min read

Drug That Targets Tauopathies in Mice Reveals Sex Differences in Response

Exposure to drugs that target tauopathies extended survival, reduced neurodegenerative biomarkers, and functionally reduced aberrant behaviors in female mice, but not in males.

Featured Neuroscience Open Neuroscience Articles

·January 17, 2023·3 min read

High Fat Diet Activates Early Inflammation in Mouse Brains, Supports Link to Neurological Disease

High-fat diets promote early inflammatory responses in the brain via an immune pathway associated with diabetes and neurodegenerative diseases. The findings suggest a link between metabolic dysfunction and cognitive impairment.

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microglia

Aging in the Brain: Microglial Changes Differ Between Sexes

Motherly Love? Immune System Changes May Play a Role

Microglia’s Role in Controlling Anxiety and OCD

Understanding Microglia’s Dual Roles Could Aid Brain Protection

Microglia Less Active in Those With Depression

Unique Microglia Subset Crucial for Cognitive Functioning

Human Brain Organoids Reveal How Microglia Develop and Function

Fresh Understanding of Aging in the Brain Offers Hope for Treating Neurological Diseases

How Our Brains Turn Into Smarter Disease Fighters

Calcium Channels Regulate Neuroinflammation and Neuropathic Pain

Drug That Targets Tauopathies in Mice Reveals Sex Differences in Response

High Fat Diet Activates Early Inflammation in Mouse Brains, Supports Link to Neurological Disease

Gene Key to MS Immune Regulation Discovered

Maternal Depression Linked to Weaker Bonds

Study Challenges Link Between Football and Brain Protein Buildup

Spotting Silent Scars: A New Way to Detect Childhood Abuse

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