Children With History of Maltreatment Could Undergo an Early Maturation of the Immune System

Summary: Study links acute stress as a result of childhood maltreatment to accelerated early maturation of the immune system.

Source: University of Barcelona

Acute psychosocial stress states stimulate the secretion of an antibody type protein that is decisive in the first immune defense against infection, but only after puberty. However, children with a history of maltreatment present a similar response to that of adolescents, which suggests there is an early maturation of the immune system in these cases.

This is one of the main conclusions of an international study coordinated by Professor Lourdes Fañanás, from the Faculty of Biology and the Institute of Biomedicine of the University of Barcelona (IBUB), with participation of the groups from the Mental Health Networking Biomedical Center (CIBERSAM).

This study, published in the journal Brain, Behavior, and Immunity, includes the participation of researchers from the CIBERSAM groups at the Hospital Clínic de Barcelona, IDIBAPS, University Hospital Gregorio Marañón (Madrid), the University Hospital Puerta del Hierro (Majadahonda, Madrid), and the University Hospital Araba—Santiago Apostol (Vitoria, Basque Country). Among the collaborators are the Unit of Adolescent Crisis Germanes Hospitalàries Sant Boi, the Adolescent-Day Hospital in Gavà (Orienta Foundation), and the Adolescent-Day Hospital in Galdakao.

The team analyzed the behavior of the secretory immunoglobulin A (s-IgA) through saliva—a less invasive biological sample compared to blood tests—in acute psychosocial stress in children and adolescents, so as to explore the potential variability according to the developmental stage and history of child maltreatment.

The study involved 94 children and adolescents aged from 7 to 17 as participants (54 of them with a psychiatric diagnosis) from a broader Spanish study (EPI-Young Stress Project). To assess their biological reactivity to stress, they provided five samples of saliva during a Trier social stress test for children (TSST-C)—a standardized protocol to analyze the biological response to acute stress in a controlled and reliable way—for the specific analysis of s-IgA and cortisol levels.

As part of the study, “we associated the acute psychological stress s-IgA secretion with the time after puberty, but children with a history of maltreatment presented a similar response. This is the first scientific study to ever explore this, and it is essential to have more studies to confirm the value of the secretory immunoglobulin A as a biomarker of acute stress,” notes Professor Lourdes Fañanás, member of the Department of Evolutionary Biology, Ecology and Environmental Sciences of the UB and principal researcher of the CIBERSAM group.

Exposure to stress leads to the activation of several biological processes that aim to mount an efficient response to a threatening situation and they later restore the homeostasis when the stressor ends.

The changes involved in the stress response depend on the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HHA), and each involves a quick adaptive response, known as the fight-or-flight response.

The SNS activates the immune system—characterized by the activation of inflammatory processes—which could be altered after long periods of chronic stress (such as maltreatment).

Symptoms of an accelerated biological aging

The study states that the measurement of s-IgA could be a feasible biomarker to explore the peripheral immune reactivity to stress in young populations. Specifically, the researchers observed that, although children and adolescents presented similar s-IgA basal levels, their s-IgA reactivity to stress seemed to differ since the former showed an increase after the stressor rapid recovery, while the latter did not show a s-IgA response.

This shows a sad child holding onto a fence
Exposure to stress leads to the activation of several biological processes that aim to mount an efficient response to a threatening situation and they later restore the homeostasis when the stressor ends. Image is in the public domain

“However, we observed that children exposed to situations of maltreatment presented a response-to-stress pattern similar to that of the adolescents,” notes Laia Marques-Feixa (UB-IBUB-CIBERSAM), first author of the paper.

As noted by Águeda Castro, co-author of the study, “this phenomenon could be in line with the widespread theories that defend that individuals exposed to a wide range of pernicious exposures—of psychosocial and chemical nature—experience what is known as accelerated biological aging.”

“However, we need more studies to elucidate the role of the history of child maltreatment and the developmental stage in the regulation of the immune system of the young people.”

Moreover, these maltreatment-associated alterations in the immune system “could have a high impact, since the deregulation of this system affects the whole organism, and has been related to different pathologies, both physical and mental, in the short and long term,” notes Laia Marques-Feixa.

About this neurodevelopment and immune system research news

Author: Press Office
Source: University of Barcelona
Contact: Press Office – University of Barcelona
Image: The image is in the public domain

Original Research: Open access.
Secretory immunoglobulin A (s-IgA) reactivity to acute psychosocial stress in children and adolescents: The influence of pubertal development and history of maltreatment” by Laia Marques-Feixa et al. Brain, Behavior, and Immunity


Secretory immunoglobulin A (s-IgA) reactivity to acute psychosocial stress in children and adolescents: The influence of pubertal development and history of maltreatment


Mucosal secretory immunoglobulin A (s-IgA) is an antibody protein-complex that plays a crucial role in immune first defense against infection. Although different immune biomarkers have been associated with stress-related psychopathology, s-IgA remains poorly studied, especially in youth.


The present study investigated how s-IgA behaves in front of acute psychosocial stress in children and adolescents, including possible variability associated with developmental stage and history of childhood maltreatment (CM).


94 children and adolescents from 7 to 17 years (54 with a current psychiatric diagnostic and 40 healthy controls) drawn from a larger Spanish study were explored (EPI-Young Stress Project). To assess biological reactivity, participants provided five saliva samples during an acute laboratory-based psychosocial stressor, the Trier Social Stress Test for Children (TSST-C). Samples were assayed for s-IgA, as well as for cortisol. Pubertal development was ascertained by Tanner stage and CM following TASSCV criteria.


We observed s-IgA fluctuations throughout the stressor, indicating the validity of TSST-C to stimulate s-IgA secretion (F(4,199) = 6.200, p <.001). Although s-IgA trajectories followed a reactivity and recovery pattern in adolescents, children exhibited no s-IgA response when faced with stress (F(4,197) = 3.406, p =.010). An interaction was found between s-IgA and CM (F(4,203) = 2.643, p =.035). Interestingly, an interaction between developmental stage, CM history and s-IgA reactivity was identified (F(12,343) = 2.036, p =.017); while children non-exposed to maltreatment exhibited no s-IgA changes to acute stress, children with a history of CM showed a similar response to adolescents, increasing their s-IgA levels after the psychosocial stressor.


Acute psychosocial stress stimulates s-IgA secretion, but only after puberty. However, children with a history of maltreatment exhibited a response resembling that of adolescents, suggesting an early maturation of the immune system. Further studies are needed to clarify the validity of s-IgA as an acute stress biomarker, including additional measures during stress exposure.

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  1. I read sometime in the past that children with a history of being abused had a greater incidence of allergies, which I think resultn from an overreacrive immune system. Makes sense with the information discussed in this research,

  2. Now Equate this Reality, to the Residual Effects of a Traumatic Birth Experience, and all the ‘Artificial’ and often very ‘Unnecessary’ current Obstetric Intervention, Restrictive Positioning, Pre-Term ‘Induction’ of Labour, Early Cord Clamping,Epidurals etc etc. The ‘Elephant in the Room’ and certainly the ‘Biologically Plausable Explination’ why such a high percentage of today’s infants present with diverse ‘Neurodevelopmental Disabilty’ from a Combination of Severe Birth Related Trauma and the negative consequences of Vaccine ‘Viral/ Toxin’ associated Neurological infection and accumulative Toxic Injury – AUTISM.


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