Summary: Researchers have discovered another purpose for the gut-brain axis; relaying information to the hippocampus to store information about our environment and location.Source: USC.Ask anyone if they remember where they ate the juiciest burger, the sweetest cupcake or the smoothest bisque, and they probably can describe the location in great detail, down to the cross streets, the décor, and the table where they sat. A new USC study in Nature Communications gives a possible explanation for food’s prominence in memory.The body’s longest nerve, the vagus nerve, is the autobahn between what scientists have referred to as the “two brains” — the one in your head and the other in your gastrointestinal tract. The nerve is key for telling you the tank is full and to put the fork down because it helps transmit biochemical signals from the stomach to the most primitive part of the brain, the brainstem.But in this animal study, researchers may have found a greater purpose behind this complex circuitry involving the vagus nerve. This “gut-brain axis” may help you remember where you ate by directing signals to another part of the brain, the hippocampus, the memory center.Following our stomachThe scientists believe that this gut instinct, this connection between spatial awareness and food, is likely a neurobiological mechanism that dates back ages to when the definition of fast food was a herd of deer running away from the nomadic hunters who tracked them.Back then especially, it would be critical for the gut to work with the brain like a Waze or Google Maps navigation app, said Scott Kanoski, an assistant professor of biological sciences at USC Dornsife and corresponding author of the paper. Those wandering early humans could remember a site where they had found and collected food and return repeatedly for more.“When animals find and eat a meal, for instance, the vagus nerve is activated and this global positioning system is engaged,” Kanoski said. “It would be advantageous for an animal to remember their external environment so that they could have food again.”The study was published on June 5.Disruption disorients the internal compassTo examine this gut-brain connection, the research team conducted the study on rats. They saw that rats with their gut-brain vagus nerve pathway disconnected could not remember information about their environment.The scientists believe that this gut instinct, this connection between spatial awareness and food, is likely a neurobiological mechanism that dates back ages to when the definition of fast food was a herd of deer running away from the nomadic hunters who tracked them. NeuroscienceNews.com image is in the public domain.“We saw impairments in hippocampal-dependent memory when we cut off the communication between the gut and the brain,” said lead author Andrea Suarez, a PhD candidate in biological sciences. “These memory deficits were coupled with harmful neurobiological outcomes in the hippocampus.”Specifically, the disconnected pathway affected markers in the brain that are key for the growth of new neural connections and new brain cells.However, it did not appear to affect the rats’ anxiety levels or their weight, the scientists noted.The scientists wrote that their findings may raise an important and timely medical question that merits further exploration: Could bariatric surgeries or other therapies that block gut-to-brain signaling affect memory?[divider]About this neuroscience research article[/divider]Funding: The study was supported by a National Institutes of Health grant to Kanoski (DK104897) and to study co-author Guillame de Lartigue at Yale University (DK094871).See alsoFeaturedNeuroscienceNeuroscience VideosPsychology·March 9, 2020The brain has two systems for thinking about others’ thoughtsOther co-authors were Ted M. Hsu, Clarissa M. Liu, Emily Noble, Alyssa Cortella, Emily Nakamoto, and Joel Hahn, all in biological sciences at USC Dornsife.Source: Emily Gersema – USC Publisher: Organized by NeuroscienceNews.com. Image Source: NeuroscienceNews.com image is in the public domain. Original Research: Open access research for “Gut vagal sensory signaling regulates hippocampus function through multi-order pathways” by Andrea N. Suarez, Ted M. Hsu, Clarissa M. Liu, Emily E. Noble, Alyssa M. Cortella, Emily M. Nakamoto, Joel D. Hahn, Guillaume de Lartigue & Scott E. Kanoski in Nature Communications. Published June 5 2018 doi:10.1038/s41467-018-04639-1 [divider]Cite This NeuroscienceNews.com Article[/divider][cbtabs][cbtab title=”MLA”]USC “‘Gut Instinct’ May Have Been the GPS of Human Ancestors.” NeuroscienceNews. NeuroscienceNews, 13 June 2018. <https://neurosciencenews.com/gut-microbiome-memory-9328/>.[/cbtab][cbtab title=”APA”]USC (2018, June 13). ‘Gut Instinct’ May Have Been the GPS of Human Ancestors. NeuroscienceNews. Retrieved June 13, 2018 from https://neurosciencenews.com/gut-microbiome-memory-9328/[/cbtab][cbtab title=”Chicago”]USC “‘Gut Instinct’ May Have Been the GPS of Human Ancestors.” https://neurosciencenews.com/gut-microbiome-memory-9328/ (accessed June 13, 2018).[/cbtab][/cbtabs]AbstractGut vagal sensory signaling regulates hippocampus function through multi-order pathwaysThe vagus nerve is the primary means of neural communication between the gastrointestinal (GI) tract and the brain. Vagally mediated GI signals activate the hippocampus (HPC), a brain region classically linked with memory function. However, the endogenous relevance of GI-derived vagal HPC communication is unknown. Here we utilize a saporin (SAP)-based lesioning procedure to reveal that selective GI vagal sensory/afferent ablation in rats impairs HPC-dependent episodic and spatial memory, effects associated with reduced HPC neurotrophic and neurogenesis markers. To determine the neural pathways connecting the gut to the HPC, we utilize monosynaptic and multisynaptic virus-based tracing methods to identify the medial septum as a relay connecting the medial nucleus tractus solitarius (where GI vagal afferents synapse) to dorsal HPC glutamatergic neurons. We conclude that endogenous GI-derived vagal sensory signaling promotes HPC-dependent memory function via a multi-order brainstem–septal pathway, thereby identifying a previously unknown role for the gut–brain axis in memory control.[divider]Feel free to share this Neuroscience News.[/divider]Join our Newsletter I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information )Sign up to receive the latest neuroscience headlines and summaries sent to your email daily from NeuroscienceNews.comWe hate spam and only use your email to contact you about newsletters. We do not sell email addresses. You can cancel your subscription any time.