The activation of a neural circuit comprising of the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the first hours following sepsis infection induced anxiety behaviors in mice two weeks after the infection cleared. The behaviors mimicked the PTSD symptoms patients experience following sepsis infection.
A new study sheds light on the gut-to-brain osmolality signaling that regulates thirst, revealing a sensory pathway that mediates the process.
A recent study found 42% of participants gained, on average, 29 lb of unwanted weight during the pandemic, with people gaining 1.5lb per month. Researchers say a combination of stress, hormones, and dwindling motivation to exercise during the lockdowns may be to blame.
The hunger hormone ghrelin doesn't just influence where and when animals eat, it also appears to have an impact on memory. Disrupting signaling of ghrelin to the vagus nerve caused rats to forget they had just eaten, even though the animals remembered they had just had access to food. Findings suggest disrupted ghrelin signaling could negatively impact episodic memory.
For the 15% of American adults who suffer from frequent indigestion or functional dyspepsia, a new, non-invasive treatment may provide some relief. Respiratory-gated Auricular Vagal Afferent Nerve Stimulation (RAVANS), a form of taVNS, delivers short pulses of painless electrical current to the vagus nerve in tune with respiratory rhythms. The device can modulate the stomach's response to food ingestion, which is often impaired in those with functional dyspepsia.
Study reveals a novel learning process orchestrated between the digestive system and brain that compels animals to seek out novel foods.
Non-invasive auricular transcutaneous vagus nerve stimulation (atVNS), applied to an accessible area of the ear, improves memory in mouse models of intellectual disability.
Lewy body disorders, including Parkinson's disease and Lewy body dementia, comprise of two distinct subtypes. One subtype originates in the peripheral nervous system (PNS) of the gut and spreads to the brain. The other originates in the brain, or enters the brain via the olfactory system, before spreading to the brainstem and PNS.
Transcutaneous vagus nerve stimulation helps improve sleep patterns and mental health in aging people. The therapy works by increasing parasympathetic activity and decreasing sympathetic activity.