Study Provides Better Insight Into the Vagus Nerve’s Link to the Brain

Summary: Using stimulation, researchers found a direct connection between the vagus nerve and learning centers of the brain. Vagus nerve stimulation, they discovered, increases learning in a healthy nervous system.

Source: University of Colorado

Researchers at the University of Colorado Anschutz Medical Campus have shown a direct link between vagus nerve stimulation and its connection to the learning centers of the brain. The discovery may lead to treatments that will improve cognitive retention in both healthy and injured nervous systems.

The study was published last week in the journal Neuron.

“We concluded that there is a direct connection between the vagus nerve, the cholinergic system that regulates certain aspects of brain function, and motor cortex neurons that are essential in learning new skills,” said Cristin Welle, PhD, senior author of the paper and the vice chair of research for the Department of Neurosurgery at the University of Colorado School of Medicine.  

“This could provide hope to patients with a variety of motor and cognitive impairments, and someday help healthy individuals learn new skills faster.”

Researchers taught healthy mice a task that’s normally difficult to see if it could help improve learning. They discovered that stimulating the vagus nerve during the process helped them learn the task much faster and achieve a higher performance level. This showed that vagus nerve stimulation can increase learning in a healthy nervous system.

The vagus nerve is critical because it regulates internal organ functions like digestion, heart rate and respiration. It also helps control reflex actions like coughing, swallowing and sneezing.

The study also revealed a direct connection between the vagus nerve and the cholinergic system that’s essential for learning and attention. Each time the vagus nerve was stimulated, researchers could observe the neurons that control learning activated within the cholinergic system.

This shows a brain
This showed that vagus nerve stimulation can increase learning in a healthy nervous system. Image is in the public domain

Damage to this system has been linked to Alzheimer’s disease, Parkinson’s disease and other motor and cognitive conditions. Now that this connection has been established in healthy nervous systems, Welle said it could lead to better treatment options for those whose systems have been damaged.

“The idea of being able to move the brain into a state where it’s able to learn new things is important for any disorders that have motor or cognitive impairments,” she said.

“Our hope is that vagus nerve stimulation can be paired with ongoing rehabilitation in disorders for patients who are recovering from a stroke, traumatic brain injury, PTSD or a number of other conditions.”

In addition to the study, Welle and her team have applied for a grant that would allow them to use a non-invasive device to stimulate the vagus nerve to treat patients with multiple sclerosis who have developed movement deficits. She’s also hoping this device could eventually help healthy people learn new skills faster.

“I think there’s a huge untapped potential for using vagus nerve stimulation to help the brain heal itself,” she said. “By continuing to investigate it, we can ultimately optimize patient recovery and open new doors for learning.”

About this neuroscience research news

Author: Laura Kelley
Source: University of Colorado
Contact: Laura Kelley – University of Colorado
Image: The image is in the public domain

Original Research: Closed access.
Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement” by Cristin Welle et al. Neuron


Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement


  • VNS paired with success enhances skilled motor learning in healthy animals
  • Enhanced motor performance is due to accelerated consolidation of an expert motor plan
  • Enhanced motor learning depends on cholinergic neural activity in the basal forebrain
  • In primary motor cortex, VNS specifically modulates outcome-activated neurons


Vagus nerve stimulation (VNS) is a neuromodulation therapy for a broad and expanding set of neurologic conditions. However, the mechanism through which VNS influences central nervous system circuitry is not well described, limiting therapeutic optimization.

VNS leads to widespread brain activation, but the effects on behavior are remarkably specific, indicating plasticity unique to behaviorally engaged neural circuits.

To understand how VNS can lead to specific circuit modulation, we leveraged genetic tools including optogenetics and in vivo calcium imaging in mice learning a skilled reach task.

We find that VNS enhances skilled motor learning in healthy animals via a cholinergic reinforcement mechanism, producing a rapid consolidation of an expert reach trajectory. In primary motor cortex (M1), VNS drives precise temporal modulation of neurons that respond to behavioral outcome.

This suggests that VNS may accelerate motor refinement in M1 via cholinergic signaling, opening new avenues for optimizing VNS to target specific disease-relevant circuitry.

Join our Newsletter
I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information )
Sign up to receive our recent neuroscience headlines and summaries sent to your email once a day, totally free.
We hate spam and only use your email to contact you about newsletters. You can cancel your subscription any time.