Dopamine signals may guide migration of immune cells to infection sites
Dopamine may play a role in activating immune cells to migrate in the early stages of infection.... Read More...
central nervous system
A molecular switch for repairing central nervous system disorders
A global knockout of the thrombin receptor PAR1 accelerates myelin development. The findings could help with the development of treatments for diseases associated with demyelination, like multiple sclerosis.... Read More...
Early prevention of neuropathic pain
Intercepting CCL2 with specific antibodies may provide an early intervention for chronic neuropathic pain.... Read More...
Where does Parkinson’s disease start? In the brain or gut? Or both?
Lewy body disorders, including Parkinson's disease and Lewy body dementia, comprise of two distinct subtypes. One subtype originates in the peripheral nervous system (PNS) of the gut and spreads to the brain. The other originates in the brain, or enters the brain via the olfactory system, before spreading to the brainstem and PNS.... Read More...
How lymphoma cells metastasize to the brain
In aging mice, chronic inflammatory processes lead lymphoma cells which entered the brain to be retained, rather than released directly back into the blood.... Read More...
New research findings on dizziness of unknown cause
People with functional dizziness do not appear to process sensory-motor impression correctly. Instead, they rely on a stored memory model which no longer matches immediate reality.... Read More...
Persistent HIV in central nervous system linked to cognitive impairment
HIV can persist in the nervous system, even when the virus is suppressed. Even when the virus is suppressed, neurocognitive problems associated with the infection can persist.... Read More...
Gut microbes protect against neurologic damage from viral infections
A healthy and diverse microbiome is essential for quickly clearing viral infections in the nervous system to prevent risks associated with multiple sclerosis. Mice with lower gut bacteria had weaker immune responses and were unable to eliminate viruses, leading to worsening paralysis. Those treated with antibiotics before infection had fewer microglia. ... Read More...
First step to induce self-repair in the central nervous system
Severed axonal segments signal to Schwann cells to begin actin sphere formation and axon disintegration. If the process is disrupted, axon disintegration is slowed and axon fragments impair nerve regeneration.... Read More...
Discovery reveals prolific ability of Schwann cells to generate myelin
Schwann cells are much more prolific in generating myelin than previously believed. Knocking out the fbxw7 gene in mouse models, researchers discovered individual Schwann cells began to spread myelin across many axons.... Read More...
Multiple sclerosis patients at a greater risk of cancer
People with multiple sclerosis may have a greater overall risk of developing cancer than those without the autoimmune disease. The highest risks are associated with respiratory, urinary and central nervous system cancers. ... Read More...
New research shows Parkinson’s disease origins in the gut
A new study adds to the growing body of evidence that Parkinson's disease may start in the gut. Researchers found gut-to-brain propagation of alpha-synuclein spread via the vagus nerve. The study provides a more accurate model of Parkinson's progression and could lead to new treatments to halt or prevent this neurodegenerative disease.... Read More...