CRISPR gene editing created the G795A amino acid which was introduced to microglia derived from human stem cells. Researchers were able to transplant the donor microglia immune cells into humanized rodent models while administering an FDA-approved cancer drug called pexidartinib. The inclusion of the amino acid cause the donated microglia to thrive and resist the drug, while the host microglia died. The findings open the door for new methods of using microglia to treat a range of neurodegenerative disorders.
Synaptic pruning occurs as a result of mechanical tearing, a new study reveals.
New AI technology is able to detect changes to the retina and predict the risk of retinal vein occlusion. Researchers say the technology could also be used to detect heart attack and stroke risks.
Researchers discovered a structure within the octopus nervous system by which the intramuscular nerve cords, which help the cephalopod to sense its arm movements, connect arms on the opposite side of the animal.
Neural stem cells of cephalopods act in a similar way to those of vertebrates during nervous system development.
Optimal intake of B-type procyanidins, a class of polyphenols found in apples, cocoa, and red wine, is linked to metabolic and the hormesis of hemodynamic responses.
The CSF drainage pathways are similar between mice and humans, researchers discovered.
A newly developed method called sensorimotor retraining appears to be effective at treating chronic back pain.
Using stimulation, researchers found a direct connection between the vagus nerve and learning centers of the brain. Vagus nerve stimulation, they discovered, increases learning in a healthy nervous system.
Based on new findings, researchers say bone marrow transplants may be an effective treatment for ALS.
Researchers discovered both immune system and central nervous system dysfunction in animal models and people with ALS4, a genetic, juvenile, and slow-progressing form of ALS.
Despite speculation that inflammation associated with the shingles virus can increase dementia risk, researchers found little evidence to substantiate the claim.