Stimulation of the Vagus Nerve Strengthens the Communication Between the Stomach and the Brain

Summary: Non-invasive stimulation of the vagus nerve can help strengthen communication between the stomach and brain within minutes.

Source: University of Tubingen

The nervous system takes in sensory stimuli, processes them and triggers reactions such as muscle movements or pain sensations. A few years ago, a network in the brain was identified that is coupled with signals from the stomach and presumably influences the human feeling of hunger and satiety.

Now, a research team led by Prof. Dr. Nils Kroemer of the University Hospitals of Tübingen and Bonn has shown for the first time that non-invasive stimulation of the vagus nerve at the ear can strengthen the communication between stomach and brain within minutes.

The study results are currently published in Brain Stimulation.

The vagus nerve is responsible for controlling many aspects of human behavior: This cranial nerve connects several important organ systems with the brain and thus supports the transmission of endogenous signals.

These help, for example, in the goal-directed search for food by tuning the reward system for food stimuli when the stomach is empty. Previous research showed that the vagus nerve can regulate digestion via the brain. This mechanism is relevant for therapeutic applications because the vagus nerve can be stimulated non-invasively.

With a new study, the team of Ph.D. student Sophie Müller and Prof. Dr. Nils Kroemer addresses the previously unanswered question of how exactly the modulation via the brain works.

About the study

The team, consisting of scientists from the universities of Tübingen and Bonn as well as the German Institute of Human Nutrition in Potsdam and the German Center for Diabetes Research, studied a total of 31 participants.

They combined stimulation of the vagus nerve at the ear with simultaneous recording of brain activation via functional magnetic resonance imaging (MRI) and a so-called electrogastrogram.

The electrogastrogram involves placing electrodes—similar to an ECG—over the stomach to record signals from the digestive tract.

“We showed for the first time that electrical stimulation strengthens the coupling between signals from the stomach and the brain—and we can do it within a few minutes,” Prof. Kroemer said.

Kroemer leads a research group on the neurobiological basis of motivation, action, and desire (neuroMADLAB) in the field of translational psychiatry at the Department of Psychiatry and Psychotherapy at the University Hospital of Tübingen and has been Professor of Medical Psychology at the Department of Psychiatry and Psychotherapy at the University of Bonn since 2022.

The study results at a glance

The research team stimulated both the vagus nerve at the ear and, in a control condition, other nerves at the ear in participants.

This shows a brain
The vagus nerve is responsible for controlling many aspects of human behavior. Image is in the public domain

“We observed that vagus nerve stimulation increased coupling with signals from the stomach in the brainstem and midbrain,” explained Prof. Kroemer.

“These regions are important because they are the first targets of the vagus nerve in the brain. Changes in the midbrain may already mediate our actions.”

In addition, the researchers discovered that coupling with the stomach increased throughout the brain, particularly in regions that already communicate more strongly with the stomach before stimulation. Changes in coupling between the stomach and brain can be produced almost instantaneously and spread rapidly.

These findings may enable new therapeutic options. For example, Prof. Kroemer’s group is currently conducting further research into a possible application for depression, where changes in communication between the body and the brain are already considered a key factor.

Likewise, in obesity and eating disorders, stimulation of the vagus nerve could help affected individuals to restore their perception of body signals in the future.

About this brain stimulation research news

Author: Press Office
Source: University of Tubingen
Contact: Press Office – University of Tubingen
Image: The image is in the public domain

Original Research: Open access.
Vagus nerve stimulation increases stomach-brain coupling via a vagal afferent pathway” by Müller, Sophie et al. Brain Stimulation


Vagus nerve stimulation increases stomach-brain coupling via a vagal afferent pathway


Maintaining energy homeostasis is vital and supported by vagal signaling between digestive organs and the brain. Previous research has established a gastric network in the brain that is phase synchronized with the rhythm of the stomach, but tools to perturb its function were lacking.


To evaluate whether stomach-brain coupling can be acutely increased by non-invasively stimulating vagal afferent projections to the brain.


Using a single-blind randomized crossover design, we investigated the effect of acute right-sided transcutaneous auricular vagus nerve stimulation (taVNS) versus sham stimulation on stomach-brain coupling.


In line with preclinical research, taVNS increased stomach-brain coupling in the nucleus of the solitary tract (NTS) and the midbrain while boosting coupling across the brain. Crucially, in the cortex, taVNS-induced changes in coupling occurred primarily in transmodal regions and were associated with changes in hunger ratings as indicators of the subjective metabolic state.


taVNS increases stomach-brain coupling via an NTS-midbrain pathway that signals gut-induced reward, indicating that communication between the brain and the body is effectively modulated by vago-vagal signaling. Such insights may help us better understand the role of vagal afferents in orchestrating the recruitment of the gastric network which could pave the way for novel neuromodulatory treatments.

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