Summary: Study reveals how the brain utilizes forward-thinking when we try to influence others or gain social control.
Source: Mount Sinai Hospital
Humans are able to think a few steps ahead in non-social situations, such as navigating a new hiking trail or planning a vacation. A Mount Sinai study now shows that we may also do this when interacting with other people.
In an effort to understand how a sense of control over others may influence the brain’s decision-making processes, researchers at the Icahn School of Medicine at Mount Sinai tested the ability of healthy human subjects to play a bargaining game. For the first time, they found that people used “forward thinking” when trying to sway others. Forward thinking happened regardless of whether the subjects could actually influence others and appeared to be driven by neural activity in a well-known decision-making center of the brain.
“Humans are social beings. And, in our view, many psychiatric disorders are the result of problems with how the brain’s software is programmed to handle social situations. In this study we tried to understand the rules that govern how that software is programmed,” said Xiaosi Gu, PhD, Director of the Center for Computational Psychiatry at Mount Sinai. “Our results suggest that in certain social situations the brain draws on the kind of forward thinking often used when playing chess.”
The study was led by Soojung Na, PhD, a former graduate student in the Gu lab and Dongil Chung, PhD, a principal investigator at the Uslan National Institute of Science and Technology in South Korea.
The researchers specifically investigated whether forward thinking is used during times when we try to influence others, or exert “social control.” Decades of research have shown that social control can have profound effects on well-being and mental health. Although several studies have shown that forward thinking is used in non-social situations, few have investigated its role in how we interact with others.
To test this idea, the researchers initially had 48 healthy volunteers sit in a brain scanner and play different versions of the “ultimatum game,” a well-known bargaining exercise in which the subjects were asked to split $20 with an opposing team.
Initial offers always started at $5. In one, “controllable,” version of the game the rules were predictable. If the subject accepted the $5 then the next offer would be one or two dollars lower. Conversely, a rejection of the $5 led to raising the subsequent offer by the same amounts.
For the second, “uncontrollable,” version of the game, a subject’s initial decision had no effect on the following offers. Instead they were chosen randomly and were thus unpredictable. Each subject played 40 rounds, alternating between the two different versions.
Initial results showed that there were differences between how the subjects responded to the games, which suggested that they perceived and exploited the advantages posed by the predictable version. Most notably, they received higher offers, took longer to decide, and felt a greater sense of control when playing the predictable version.
The participants reported a sense of control during the unpredictable game that was much higher—around 40 percent—than reality, which was zero chance of control. Moreover, in one subset of experiments, the subjects played the games against a computer instead of teams.
Here the participants felt about 60 percent in control of the game regardless of which version they played and despite the fact that they received higher offers in the predictable version.
“These results highlight the complicated interplay between the actual controllability of social situations and our feelings of control,” said Dr. Gu.
Nonetheless, computational modeling experiments suggested that in every situation tested—predictable vs unpredictable and team vs computer—the subjects consistently used forward thinking to play the game. In other words, a computer algorithm which tested out whether a subject would think two, three, or four steps ahead before deciding on an offer recreated the initial results better than one that assumed the subjects just reacted or thought only one step ahead.
These findings were strengthened by the results of an online version of the initial experiments that was played by 1,342 participants. Again, the results showed that the predictable version of the game produced higher offers and a greater sense of control then the unpredictable one even though the simulation suggested that forward thinking was used for both.
Finally, the results of the brain scans suggested that these choices were being driven by neural activity in the ventromedial prefrontal cortex, a decision-making center known to be involved in forward thinking. For instance, the two-step forward thinking computer simulation helped explain the changes in this area of the brain better than other simulations or when applied to other brain regions.
“These results expand the role of both the ventromedial prefrontal cortex and of forward thinking in our lives,” said Dr. Gu. “In the future, we plan to explore how problems in the brain’s forward thinking app may play role in depression, schizophrenia and other neuropsychiatric disorders.”
Funding: This work was supported by the National Institutes of Health (MH120789, MH122611, and MH123069); the University of Texas, Dallas; the Ulsan National Institute of Science and Technology (South Korea, 1.180073.01); the National Research Foundation of Korea (NRF-2018R1D1A1B07043582); the Mental Illness Research, Education, and Clinical Center (MIRECC VISN 2) at the James J. Peter Veterans Affairs Medical Center (Bronx, NY); the Max Planck Society (Germany); the Alexander von Humboldt Foundation (Germany).
Humans Use Forward Thinking to Exploit Social Controllability
The controllability of our social environment has a profound impact on our behavior and mental health. Nevertheless, neurocomputational mechanisms underlying social controllability remain elusive.
Here, 48 participants performed a task where their current choices either did (Controllable), or did not (Uncontrollable), influence partners’ future proposals.
Computational modeling revealed that people engaged a mental model of forward thinking (FT; i.e., calculating the downstream effects of current actions) to estimate social controllability in both Controllable and Uncontrollable conditions. A large-scale online replication study (n=1342) supported this finding.
Using functional magnetic resonance imaging (n=48), we further demonstrated that the ventromedial prefrontal cortex (vmPFC) computed the projected total values of current actions during forward planning, supporting the neural realization of the forward-thinking model.
These findings demonstrate that humans use vmPFC-dependent FT to estimate and exploit social controllability, expanding the role of this neurocomputational mechanism beyond spatial and cognitive contexts.