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Octopuses Given Ecstasy Reveal Genetic Link to Evolution of Social Behaviors in Humans

Summary: Testing the behavioral reaction to MDMA in octopuses, researchers report they have discovered evidence of an evolutionary link between the sea creatures and humans.

Source: Johns Hopkins Medicine.

By studying the genome of a kind of octopus not known for its friendliness toward its peers, then testing its behavioral reaction to a popular mood-altering drug called MDMA or “ecstasy,” scientists say they have found preliminary evidence of an evolutionary link between the social behaviors of the sea creature and humans, species separated by 500 million years on the evolutionary tree.

A summary of the experiments is published Sept. 20 in Current Biology, and if the findings are validated, the researchers say, they may open opportunities for accurately studying the impact of psychiatric drug therapies in many animals distantly related to people.

“The brains of octopuses are more similar to those of snails than humans, but our studies add to evidence that they can exhibit some of the same behaviors that we can,” says Gül Dölen, M.D., Ph.D., assistant professor of neuroscience at the Johns Hopkins University School of Medicine and the lead investigator conducting the experiments. “What our studies suggest is that certain brain chemicals, or neurotransmitters, that send signals between neurons required for these social behaviors are evolutionarily conserved.”

Octopuses, says Dölen, are well-known to be clever creatures. They can trick prey to come into their clutches, and Dölen says there is some evidence they also learn by observation and have episodic memory. The gelatinous invertebrates (animals without backbones) are further notorious for escaping from their tank, eating other animals’ food, eluding caretakers and sneaking around.

But most octopuses are asocial animals and avoid others, including other octopuses. But because of some of their behaviors, Dölen still thought there may be a link between the genetics that guide social behavior in them and humans. One place to look was in the genomics that guide neurotransmitters, the signals that neurons pass between each other to communicate.

Dölen and Eric Edsinger, Ph.D., a research fellow at the Marine Biological Laboratory in Woods Hole, Massachusetts, took a closer look at the genomic sequence of Octopus bimaculoides, commonly referred to as the California two-spot octopus.

Specifically, in the gene regions that control how neurons hook neurotransmitters to their membrane, Dölen and Edsinger found that octopuses and humans had nearly identical genomic codes for the transporter that binds the neurotransmitter serotonin to the neuron’s membrane. Serotonin is a well-known regulator of mood and closely linked to certain kinds of depression.

an octopus

By studying the genome of a kind of octopus not known for its friendliness toward its peers, then testing its behavioral reaction to a popular mood-altering drug called MDMA or ‘ecstasy,’ scientists say they have found preliminary evidence of an evolutionary link between the social behaviors of the sea creature and humans, species separated by 500 million years on the evolutionary tree. NeuroscienceNews.com image is credited to Tom Kleindinst.

The serotonin-binding transporter is also known to be the place where the drug MDMA binds to brain cells and alters mood. So, the researchers set out to see if and/or how octopuses react to the drug, which also produces so-called pro-social behaviors in humans, mice and other vertebrates.

Dölen designed an experiment with three connected water chambers: one empty, one with a plastic action figure under a cage and one with a female or male laboratory-bred octopus under a cage.

Four male and female octopuses were exposed to MDMA by putting them into a beaker containing a liquefied version of the drug, which is absorbed by the octopuses through their gills. Then, they were placed in the experimental chambers for 30 minutes. All four tended to spend more time in the chamber where a male octopus was caged than the other two chambers.

“It’s not just quantitatively more time, but qualitative. They tended to hug the cage and put their mouth parts on the cage,” says Dölen. “This is very similar to how humans react to MDMA; they touch each other frequently.”

Under normal conditions, without MDMA, five male and female octopuses avoided only male, caged octopuses.

Dölen says the experiments suggest that the brain circuits guiding social behavior in octopuses are present in normal conditions, but may be suppressed by natural or other circumstances. “Octopuses will suspend their antisocial behavior for mating, for example. Then, when they are done mating, they go into aggressive, asocial mode,” says Dolen.

Dölen cautions the results are preliminary and need to be replicated and affirmed in further experiments before octopuses might be used as models for brain research.

About this neuroscience research article

Funding: Funding for the research was provided by the Kinship Foundation, the Hartwell Foundation, the Klingenstein-Simons Foundation and the Vetlesen Foundation.

Source: Vanessa Wasta – Johns Hopkins Medicine
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to Tom Kleindinst.
Original Research: Open access research for “A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus” by Eric Edsinger, and Gül Dölen in Current Biology. Published September 20 2018.
doi:10.1016/j.cub.2018.07.061

Cite This NeuroscienceNews.com Article
Johns Hopkins Medicine”Octopuses Given Ecstasy Reveal Genetic Link to Evolution of Social Behaviors in Humans.” NeuroscienceNews. NeuroscienceNews, 20 September 2018.
<http://neurosciencenews.com/ecstasy-octopus-social-behavior-9895/>.
Johns Hopkins Medicine(2018, September 20). Octopuses Given Ecstasy Reveal Genetic Link to Evolution of Social Behaviors in Humans. NeuroscienceNews. Retrieved September 20, 2018 from http://neurosciencenews.com/ecstasy-octopus-social-behavior-9895/
Johns Hopkins Medicine”Octopuses Given Ecstasy Reveal Genetic Link to Evolution of Social Behaviors in Humans.” http://neurosciencenews.com/ecstasy-octopus-social-behavior-9895/ (accessed September 20, 2018).

Abstract

A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus

Human and octopus lineages are separated by over 500 million years of evolution and show divergent anatomical patterns of brain organization. Despite these differences, growing evidence suggests that ancient neurotransmitter systems are shared across vertebrate and invertebrate species and in many cases enable overlapping function. Sociality is widespread across the animal kingdom, with numerous examples in both invertebrate (e.g., bees, ants, termites, and shrimps) and vertebrate (e.g., fishes, birds, rodents, and primates) lineages. Serotonin is an evolutionarily ancient molecule that has been implicated in regulating both invertebrate and vertebrate social behaviors, raising the possibility that this neurotransmitter’s prosocial functions may be conserved across evolution. Members of the order Octopoda are predominantly asocial and solitary. Although at this time it is unknown whether serotonergic signaling systems are functionally conserved in octopuses, ethological studies indicate that agonistic behaviors are suspended during mating, suggesting that neural mechanisms subserving social behaviors exist in octopuses but are suppressed outside the reproductive period. Here we provide evidence that, as in humans, the phenethylamine (+/−)-3,4-methylendioxymethamphetamine (MDMA) enhances acute prosocial behaviors in Octopus bimaculoides. This finding is paralleled by the evolutionary conservation of the serotonin transporter (SERT, encoded by the Slc6A4 gene) binding site of MDMA in the O. bimaculoides genome. Taken together, these data provide evidence that the neural mechanisms subserving social behaviors exist in O. bimaculoides and indicate that the role of serotonergic neurotransmission in regulating social behaviors is evolutionarily conserved.

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