dopamine

This shows the outline of a head and smokey lines

Researchers discover potential therapy to treat detrimental effects of marijuana

Prenatal exposure to THC makes dopamine neurons hyperactive and increases the sensitivity to the behavioral effects of the compound during pre-adolescence. This may increase the risk of developing schizophrenia later in life. However, treatment with pregnenolone, a drug under clinical trials for ASD, cannabis use disorder, and schizophrenia, appears to correct the brain abnormalities and behavioral problems associated with prenatal cannabis exposure.... Read More...
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Molecular link between chronic pain and depression revealed

Inhibitory inputs to the neural circuit between the dorsolateral bed nucleus of the stria terminalis (dlBNST) to the ventral tegmental area (VTA) increase when a person is in chronic pain. This alteration is mediated by enhanced corticotropin-releasing factor signaling within the dlBNST, leading to suppression of the mesolimbic dopaminergic system. The result is depressive mood and anhedonia associated with chronic pain.... Read More...
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Parkinson’s disease may originate in the intestines

Two months after injecting alpha-synuclein into the intestines of rats, researchers discovered the proteins had traveled to the brain via peripheral nerves. Four months later, the pathology was greater. Additionally, the protein had traveled to the heart. The study supports the hypothesis that Parkinson's disease may begin in the intestinal system before migrating to the brain. ... Read More...