Men are more likely to have a dysregulated HPA axis that is associated with depressive symptoms, while women have higher levels of binding proteins for stress hormones that may prevent dysregulation of the HPA axis. The findings shed new light on how stress hormones impact dopamine transmission and how this impacts depression on a sex-specific basis.
A common genetic signature has been linked to an increased risk of substance use disorders from smoking addiction to addiction to narcotics. The findings could pave the way to the development of new therapies for substance use disorder and may help diagnose those at risk to multiple substance use disorders.
Consuming high-fat and high-sugar foods causes changes in activity and connectivity in the brain's dopaminergic system, resulting in a stronger preference for these foods.
Researchers say Matcha, a traditional Japanese tea, can help boost mood and mental performance. Match tea powder activates dopaminergic neural networks and improves depressive symptoms in mice that previously experienced stress as a result of social isolation.
Study reveals how signals from the environment integrate with genetic information that influences the survival and health of neurons, providing new insights into how Parkinson's disease may develop. Findings reveal the TNK2 gene mutations lead to the degeneration of dopamine producing neurons, resulting in Parkinson's disease pathology.
The connection between dopamine and counterfactual information, or notions of relief and regret, is altered in those with alcohol use disorder.
Levodopa, a drug commonly prescribed for the treatment of Parkinson's disease that increases dopamine in the brain was found to reverse the effects of neuroinflammation on the reward system and improve symptoms associated with depression.
A new test that measures dopamine levels in biological fluids could help with the detection of depression, Parkinson's disease, and other disordered marked by abnormal dopamine levels.
Researchers have identified how two different populations of neurons in the striatum are affected differently in Huntington's disease. The neurodegeneration of one of these populations leads to motor defects while damage to the other population located in striosomes may account for mood disorders associated with the early stages of Huntington's.
Diphenylbutylpiperidines (DPBPs), an older class of antipsychotic medications can effectively be repurposed to help treat type 2 diabetes, a new study reports.
Researchers have developed a soft, implantable brain probe that can monitor serotonin and dopamine activity in real-time.
Study reveals how methylphenidate interacts with cognitive control networks and attention behaviors. Methylphenidate changes spontaneous neural activity in reward and cognitive control systems in children with ADHD. The changes result in more stable sustained attention.