Researchers have identified novel neurocircuitry between midbrain structures which are modulated by leptin to control eating behaviors in mice.
Dopamine neurons largely rely on their own discharge to determine release rates of the hormone, researchers report.
A recent study found 42% of participants gained, on average, 29 lb of unwanted weight during the pandemic, with people gaining 1.5lb per month. Researchers say a combination of stress, hormones, and dwindling motivation to exercise during the lockdowns may be to blame.
Mouse study reveals elevated dopamine levels preceded hallucination-like events, and artificially boosting dopamine levels induced more hallucination-like events. The behavioral effects could be blocked by administering haloperidol, an antipsychotic which blocks dopamine. The study sheds light on potential new treatments for psychotic disorders marked by hallucinations.
PINK1, a gene associated with Parkinson's disease, is not just responsible for the premature death of dopaminergic neurons, it also plays a key role in the neurogenesis of dopamine neurons throughout life.
Dopamine neurons in the midbrain become active in a previously undetected way when an animal considers a reward that is changing in value.
Focusing attention on a neural pathway starting at the periaqueductal grey region of the midbrain, researchers made a novel discovery about how dopamine generates different pain responses in male and female mice. Findings indicate dopamine may reduce pain sensitivity in males, whereas, in females, dopamine helps focus attention elsewhere in the presence of pain.
A smoking cessation drug called cytisine may be a helpful new tool for the treatment of Parkinson's disease in women. Cytisine was found to reduce the loss of dopamine neurons. The effect was more pronounced when estrogen was present.
Grafting neurons derived from a monkey's own stem cells reversed the debilitating and mental health symptoms associated with Parkinson's disease. The treatment shows promise for alleviating the symptoms of Parkinson's in humans.