Taking SSRIs and having the "long-long" serotonin SERT genetic variant lowers SERT activity in the mitral valve, leading to degenerative mitral regurgitation, one of the most common heart valve diseases.
SERT Ala56 impacts the structure of the SERT protein cells, increasing the activity of the transporter to abnormally high levels. The high-activity state results in the removal of too much serotonin from brain sites where serotonin is needed, both during development and in adults.
Genetics testing revealed those with a greater susceptibility to stress have at least one copy of a variation in the serotonin transporter gene. Additionally, changes to connections in the middle temporal gyrus related to changes in cognitive performance during stress.
Testing the behavioral reaction to MDMA in octopuses, researchers report they have discovered evidence of an evolutionary link between the sea creatures and humans.
A new Johns Hopkins University study adds further evidence to the link between serotonin and dementia. According to researchers, lower serotonin levels may play a key role in memory decline and drive the progression of Alzheimer's.
A new study reports sex hormones taken by those undergoing gender reassignment can alter brain chemistry and increase risk for mood disorders, especially in men transitioning into women.
A synthetic compound, decynium-22, is able to turn off SERT in the brain, enhancing the effectiveness of SSRIs.