SERT Ala56 impacts the structure of the SERT protein cells, increasing the activity of the transporter to abnormally high levels. The high-activity state results in the removal of too much serotonin from brain sites where serotonin is needed, both during development and in adults.
A new Johns Hopkins University study adds further evidence to the link between serotonin and dementia. According to researchers, lower serotonin levels may play a key role in memory decline and drive the progression of Alzheimer's.
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A new study reports sex hormones taken by those undergoing gender reassignment can alter brain chemistry and increase risk for mood disorders, especially in men transitioning into women.
In anxiety, neural activity becomes elevated across many specific brain regions, and normal coordination between the networks becomes decreased.
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A new study reinforces the idea that serotonin, a molecule associated with mood, directly contributes to the actions of cocaine.
Genetics testing revealed those with a greater susceptibility to stress have at least one copy of a variation in the serotonin transporter gene. Additionally, changes to connections in the middle temporal gyrus related to changes in cognitive performance during stress.
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A synthetic compound, decynium-22, is able to turn off SERT in the brain, enhancing the effectiveness of SSRIs.
A new substance named Lu AF60097 may help reduce side effects from tricyclic antidepressants in those with severe depression.
A new study reports people with a specific type of gene are more deeply affected by their life experiences. The findings challenge traditional thinking about depression.
Taking SSRIs and having the "long-long" serotonin SERT genetic variant lowers SERT activity in the mitral valve, leading to degenerative mitral regurgitation, one of the most common heart valve diseases.
According ecstasy users showed significant reductions in the way serotonin is transported in the brain.
Testing the behavioral reaction to MDMA in octopuses, researchers report they have discovered evidence of an evolutionary link between the sea creatures and humans.