Johns Hopkins Medicine

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Brain changes linked with Alzheimer’s up to 30 years before symptoms appear

Researchers have identified average levels of biological and anatomical brain changes associated with Alzheimer's disease over thirty years before symptoms appear. In those with genetic risk factors for Alzheimer's, researchers found changes in cognitive performance up to 15 years before becoming symptomatic. Changes in Tau levels in the cerebral spinal fluid appeared up to 34 years before dementia symptoms occurred, and physical changes to the medial temporal lobe were apparent up to 9 years before cognitive impairment was apparent.... Read More...
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Broccoli sprout compound may restore brain chemistry imbalance linked to schizophrenia

Sulforaphane, a compound derived from broccoli sprouts, may be a useful new treatment for those suffering from schizophrenia. In a recent set of animal and human studies, researchers characterized novel chemical imbalances in the brain related to glutamate. Levels of glutamate, they discovered, can be altered by administering sulforaphane.... Read More...
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Restoring brain function in mice with symptoms of Alzheimer’s disease

Senolytic drugs administered to mice reduced senescent cells around amyloid plaques by more than 90% and decreased neuroinflammation by 50%. Mice treated with the drug combination also showed improvements in spatial memory, compared to other Alzheimer's model mice who received no treatment. The findings could have positive implications for the treatment of Alzheimer's disease in people with the condition.... Read More...
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Psychedelic drug MDMA may reawaken ‘critical period’ in brain to help treat PTSD

MDMA, a psychedelic drug, has successfully been used to reopen the 'critical period' of learning the reward values of social behaviors. Researchers report, in mature mice given MDMA, oxytocin triggers signaling in synapses that help encode social learning and memory, a process that does not usually occur in older animals. The findings could help in the development of treatments for PTSD and other disorders.... Read More...
hip location

Hip Fractures May Be An Early Sign of Alzheimer’s in Older People

Researchers report they have identified biomarkers of Alzheimer's disease in spinal fluid samples of a significant number of older patients hospitalized as a result of hip fractures. The study suggests neural alterations that lead to poor balance in older people may signify an increased risk of falls that result in hip fractures, and Alzheimer's disease. Researchers suggest the hip fracture, therefore, may serve as an early sign of Alzheimer's in older patients.... Read More...
brain scans

New Scan Technique Reveals Neuroinflammation Associated with Post-Treatment Lyme Disease Syndrome

A new neuroimaging study reveals 12 people with documented post-treatment Lyme disease syndrome have an elevation of a chemical marker associated with neuroinflammation. The findings could help develop new treatments for the pain, fatigue and brain fog associated with PTLDS.... Read More...