Disorders of compulsivity share common pattern and brain structure.
People affected by binge eating, substance abuse and obsessive compulsive disorder all share a common pattern of decision making and similarities in brain structure, according to new research from the University of Cambridge.
In a study published in the journal Molecular Psychiatry and primarily funded by the Wellcome Trust, researchers show that people who are affected by disorders of compulsivity have lower grey matter volumes (in other words, fewer nerve cells) in the brain regions involved in keeping track of goals and rewards.
In our daily lives, we make decisions based either on habit or aimed at achieving a specific goal. For example, when driving home from work, we tend to follow habitual choices – our ‘autopilot’ mode – as we know the route well; however, if we move to a nearby street, we will initially follow a ‘goal-directed’ choice to find our way home – unless we slip into autopilot and revert to driving back to our old home. However, we cannot always control the decision-making process and make repeat choices even when we know they are bad for us – in many cases this will be relatively benign, such as being tempted by a cake whilst slimming, but extreme cases it can lead to disorders of compulsivity.
In order to understand what happens when our decision-making processes malfunction, a team of researchers led by the Department of Psychiatry at the University of Cambridge compared almost 150 individuals with disorders including methamphetamine dependence, obesity with binge eating and obsessive compulsive disorder, comparing them with healthy volunteers of the same age and gender.
Study participants first took part in a computerised task to test their ability to make choices aimed a receiving a reward over and above making compulsive choices. In a second study, the researchers compared brain scans taken using magnetic resonance imaging (MRI) in healthy individuals and a subset of obese individuals with or without binge eating disorder (a subtype of obesity in which the person binge eats large amounts of food rapidly).
The researchers demonstrated that all of the disorders were connected by a shift away from goal-directed behaviours towards automatic habitual choices. The MRI scans showed that obese subjects with binge eating disorder have lower grey matter volumes – a measure of the number of neurons – in the orbitofrontal cortex and striatum of the brain compared to those who do not binge eat; these brain regions are involved in keeping track of goals and rewards. Even in healthy volunteers, lower grey matter volumes were associated with a shift towards more habitual choices.
Dr Valerie Voon, principal investigator of the study, says: “Seemingly diverse choices – drug taking, eating quickly despite weight gain, and compulsive cleaning or checking – have an underlying common thread: rather that a person making a choice based on what they think will happen, their choice is automatic or habitual.
“Compulsive disorders can have a profoundly disabling effect of individuals. Now that we know what is going wrong with their decision making, we can look at developing treatments, for example using psychotherapy focused on forward planning or interventions such as medication which target the shift towards habitual choices.”
Notes about this neuropsychology research
Contact: Valerie Voon – University of Cambridge Source:University of Cambridge press release Image Source: The image is credited to Dave 77459 and is adapted from the University of Cambridge press release. The image is licensed Creative Commons Attribution-Non Commercial-ShareAlike 3.0 Unported Original Research: Full open access research for “Disorders of compulsivity: a common bias towards learning habits” by V Voon, K Derbyshire, C Rück, M A Irvine, Y Worbe, J Enander, L R N Schreiber, C Gillan, N A Fineberg, B J Sahakian, T W Robbins, N A Harrison, J Wood, N D Daw, P Dayan, J E Grant and E T Bullmore in Molecular Psychiatry. Published online May 20 2014 doi:10.1038/mp.2014.44
Open Access Neuroscience Abstract
Disorders of compulsivity: a common bias towards learning habits
Why do we repeat choices that we know are bad for us? Decision making is characterized by the parallel engagement of two distinct systems, goal-directed and habitual, thought to arise from two computational learning mechanisms, model-based and model-free. The habitual system is a candidate source of pathological fixedness. Using a decision task that measures the contribution to learning of either mechanism, we show a bias towards model-free (habit) acquisition in disorders involving both natural (binge eating) and artificial (methamphetamine) rewards, and obsessive-compulsive disorder. This favoring of model-free learning may underlie the repetitive behaviors that ultimately dominate in these disorders. Further, we show that the habit formation bias is associated with lower gray matter volumes in caudate and medial orbitofrontal cortex. Our findings suggest that the dysfunction in a common neurocomputational mechanism may underlie diverse disorders involving compulsion.
“Disorders of compulsivity: a common bias towards learning habits” by V Voon, K Derbyshire, C Rück, M A Irvine, Y Worbe, J Enander, L R N Schreiber, C Gillan, N A Fineberg, B J Sahakian, T W Robbins, N A Harrison, J Wood, N D Daw, P Dayan, J E Grant and E T Bullmore in Molecular Psychiatry, May 20 2014 doi:10.1038/mp.2014.44