The delicate balance between learning new behaviors and expressing old habits is controlled by two different populations of neurons in the dorsolateral striatum.
People show a decrease in motivation to exert effort or work when feeling fatigued. Motivation can be restored if people are allowed a short rest, however for those with long-term fatigue, motivation does not improve following a short-term period of rest.
Huntington's disease may progress to advanced stages as a result of degradation of the cells' health maintenance system than due to the increased disease pathology itself.
Astrocytes in the striatum appear to play a critical role in stuttering. Researchers found treatment with risperidone helped reduce stuttering by increasing the metabolism of striatal astrocytes.
Researchers recorded alterations in levels of both dopamine and serotonin in the brain when people perform perception and decision making based tasks.
Researchers found specific neurons in the striosome that help mice learn to avoid negative experiences.
Study reports the putamen, not just the cortex, contributes to the brain's ability to multitask.
Dopamine receptors have different molecular features and functions depending on their anatomical location within the striatum. The findings could help develop better-targeted treatments for a range of disorders from schizophrenia to Parkinson's disease.