The striatum and premotor cortex show altered patterns in neural activity when encoding time. The dynamics of the striatum were more sequential than those of the premotor cortex. Read More
Researchers found specific neurons in the striosome that help mice learn to avoid negative experiences. Read More
Study reports the putamen, not just the cortex, contributes to the brain's ability to multitask. Read More
Dopamine receptors have different molecular features and functions depending on their anatomical location within the striatum. The findings could help develop better-targeted treatments for a range of disorders from schizophrenia to Parkinson's disease. Read More
Involuntary movements and tremors caused as a result of taking dopamine replacement medications for Parkinson's disease can be alleviated through the suppression of RasGRP1. Read More
Neuroimaging reveals how dopamine released from the striatum influences brain activity in the motor cortex and insular. Read More
During memory tasks, people with psychosis have different patterns of activity in the prefrontal and mediotemporal brain areas compared to those without the disorder. When exposed to cannabidiol (CBD), the activity of the brain areas became more like those seen in the controls for people with psychosis. Patients reported a decrease in symptoms of psychosis following one dose of CBD. Researchers stress that no definitive conclusions could be made about the effectiveness of CBD use over a sustained period. Read More
10% of patients diagnosed with Parkinson's disease are between the ages of 21 and 50. For those with young-onset Parkinson's disease, researchers report the foundations for the disease may have been apparent before they were born. The study also points to a drug, currently approved to treat precancerous skin growths, that has the potential to reduce elevated levels of alpha-synuclein. Read More
Methylphenidate may boost norepinephrine levels in the prefrontal cortex, which in turn regulates dopaminergic neurons firing in the striatum, when a reward is delivered. The study sheds new light on how medications for ADHD affect the reward system in the brain. Read More
Using RNA sequencing, researchers have created a spatiomolecular map of the striatum, an area of the brain implicated in decision making and addiction. Read More
Mu-opioid receptor (MOR) levels are significantly reduced in the striatum in those with schizophrenia. A lack of MOR system stimulation contributes to negative feelings, such as a lack of motivation and anhedonia, associated with the condition. Increasing MOR levels could help to reduce some of the symptoms of schizophrenia. Read More
Researchers have identified a comprehensive circuit mechanism that governs how emotional states can influence movement through connections in the basal ganglia. The mechanism represents a way in which emotional states relate to changes in action control in depression, anxiety, and OCD. Read More
