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          striatum

          This shows a person holding a cup of wateri
          FeaturedGeneticsNeurologyNeuroscience
          ·May 1, 2020·5 min read

          Parkinson’s dyskinesia mechanism explained

          Involuntary movements and tremors caused as a result of taking dopamine replacement medications for Parkinson's disease can be alleviated through the suppression of RasGRP1.
          Read More
          This shows brain scans from the study
          FeaturedNeuroscience
          ·April 1, 2020·5 min read

          How dopamine drives brain activity

          Neuroimaging reveals how dopamine released from the striatum influences brain activity in the motor cortex and insular.
          Read More
          This shows a brain
          FeaturedNeurosciencePsychology
          ·January 29, 2020·4 min read

          How CBD takes effect in the brains of people with psychosis

          During memory tasks, people with psychosis have different patterns of activity in the prefrontal and mediotemporal brain areas compared to those without the disorder. When exposed to cannabidiol (CBD), the activity of the brain areas became more like those seen in the controls for people with psychosis. Patients reported a decrease in symptoms of psychosis following one dose of CBD. Researchers stress that no definitive conclusions could be made about the effectiveness of CBD use over a sustained period.
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          This shows a pregnant woman
          FeaturedGeneticsNeurologyNeuroscience
          ·January 27, 2020·5 min read

          Parkinson’s disease may start before birth

          10% of patients diagnosed with Parkinson's disease are between the ages of 21 and 50. For those with young-onset Parkinson's disease, researchers report the foundations for the disease may have been apparent before they were born. The study also points to a drug, currently approved to treat precancerous skin growths, that has the potential to reduce elevated levels of alpha-synuclein.
          Read More
          This shows the mPFC and striatum highligted on a brain scan
          FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology
          ·January 17, 2020·5 min read

          Rich rewards: ADHD medication’s effect on the brain

          Methylphenidate may boost norepinephrine levels in the prefrontal cortex, which in turn regulates dopaminergic neurons firing in the striatum, when a reward is delivered. The study sheds new light on how medications for ADHD affect the reward system in the brain.
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          This shows the striatum
          FeaturedNeuroscienceOpen Neuroscience Articles
          ·December 27, 2019·3 min read

          A molecular map of the brain’s decision-making area

          Using RNA sequencing, researchers have created a spatiomolecular map of the striatum, an area of the brain implicated in decision making and addiction.
          Read More
          This shows brain networks
          FeaturedNeurosciencePsychology
          ·October 4, 2019·3 min read

          Promising steps towards hope for a treatment for schizophrenia

          Mu-opioid receptor (MOR) levels are significantly reduced in the striatum in those with schizophrenia. A lack of MOR system stimulation contributes to negative feelings, such as a lack of motivation and anhedonia, associated with the condition. Increasing MOR levels could help to reduce some of the symptoms of schizophrenia.
          Read More
          This shows neurons in the basal ganglia
          FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology
          ·September 13, 2019·4 min read

          How emotion affects action

          Researchers have identified a comprehensive circuit mechanism that governs how emotional states can influence movement through connections in the basal ganglia. The mechanism represents a way in which emotional states relate to changes in action control in depression, anxiety, and OCD.
          Read More
          This shows brain scans
          FeaturedNeurosciencePsychology
          ·August 27, 2019·4 min read

          Neurological brain markers might detect risk for psychotic disorders

          Researchers have identified a new biomarker for psychosis in the striatal dopamine neurons. Those at risk for psychosis showed increased activation in the striatum for positive feedback and decreased activation when faced with negative feedback.
          Read More
          This shows a watercolor of a person walking
          FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology
          ·August 1, 2019·3 min read

          Brain activity may help predict success of CBT in depression

          Only 45% of patients with major depressive disorder find benefit from cognitive behavioral therapy (CBT). A neuroimaging study reveals those who respond to CBT have greater neural activity in the right striatum and right amygdala pretreatment than those who find little benefit from the treatment. The findings could serve as a biomarker to discover who will respond to CBT.
          Read More
          This shows a child looking at a DNA double helix
          AutismFeaturedGeneticsNeuroscienceOpen Neuroscience Articles
          ·July 25, 2019·4 min read

          Brain protein mutation from child with autism causes autism-like behavioral change in mice

          Researchers implanted a genetic mutation that encodes the DAT protein from a child with ASD into mice. The mice began to exhibit autism-like behavioral deficits. Mice with the DAT T356M mutation had reduced social interaction and a loss in social dominance. The mice also demonstrated an increase in hyperactivity. At the physiological level, the researchers found impaired striatal dopamine transmission and clearance.
          Read More
          This shows a brain
          FeaturedNeuroscience
          ·July 23, 2019·5 min read

          Study Advances Understanding of How Brains Remember Decisions

          The medial prefrontal cortex persistently encodes value based decision variables.
          Read More
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          This shows an empty bottle in sand.

          Rising Temperatures Show Climate’s Hidden Impact on Substance Use

          This shows a maze.

          ChatGPT’s Choices: Overload or Overjoyed? Decoding Decision Dynamics

          This shows worms.

          Worms Illuminate Ancient Emotional Mechanisms

          This shows a brain.

          Probing E-Cig and Alcohol’s Joint Assault on the Blood-Brain Barrier

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