Dopamine receptors have different molecular features and functions depending on their anatomical location within the striatum. The findings could help develop better-targeted treatments for a range of disorders from schizophrenia to Parkinson's disease.
Researchers found specific neurons in the striosome that help mice learn to avoid negative experiences.
Researchers report the striatum and amygdala are less able to track changes in threat levels in those with severe PTSD. The findings may serve as a biomarker to evaluate who may be at greater risk of PTSD symptoms.
Researchers recorded alterations in levels of both dopamine and serotonin in the brain when people perform perception and decision making based tasks.
Using RNA sequencing, researchers have created a spatiomolecular map of the striatum, an area of the brain implicated in decision making and addiction.
A neuroimaging study reveals people with OCD who receive daily cognitive behavioral therapy to help curb their compulsive behaviors show stronger connections between specific brain regions.
Exposing mice with the autism-associated SHANK3 genetic mutation to new environments can trigger autism-like behaviors, including repetitive movements and problems with social engagement. However, adding familiar objects to the novel environment during the first exposure can reduce the behavioral and brain signaling deficits.
According to a new study, habit formation is driven by neurons in the striatum which represent both the cost and reward of the behavior.
Researchers characterize a novel neural population within the striatum that appears to be responsible for the interplay between acetylcholine and GABA.
People with a variation of the DRD2 gene are more resilient to the effects of sleep deprivation when completing tasks that require cognitive flexibility, a new study reports.