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orbitofrontal cortex

Featured Neurology Neuroscience Psychology

·September 15, 2026·5 min read

Brain Activity Predicts Risky Choices Half a Second Before They Are Made

Scientists discover opposing brain circuits in the orbitofrontal cortex that predict risky choices 500 ms before they occur.

Featured Neuroscience

·July 30, 2026·9 min read

The Neural Signal of Curiosity and Information Value

A new study reveals that mice pay a physical reward cost to gain advance information, driven by a distinct population of orbitofrontal cortex neurons that encode the intrinsic value of knowledge.

Featured Neuroscience

·July 27, 2026·6 min read

3-Region Neural Circuit Required for Sleep Memory

A new study reveals that memory consolidation during sleep requires coordinated signaling among the orbitofrontal cortex, thalamus, and hippocampus, and shows how epileptic spikes break this circuit.

This shows two heads and brains. One brain in like a circuit network.

Neuroscience

·July 27, 2026·7 min read

Dual Brain Circuits Drive Habit Formation

While the ACC-to-RSC pathway determines if a behavior becomes a habit, the lOFC-to-central striatum circuit regulates execution intensity, explaining individual habit differences.

Featured Neuroscience Psychology

·July 7, 2026·13 min read

Causal Network Mapping Isolates Core Brain Circuits of OCD

By tracing 40 cases of lesional OCD against the human connectome, the team isolated four core hubs, the orbitofrontal cortex and basal ganglia bilaterally, providing a highly accurate network target for precision rTMS therapy.

This shows a diagram of a brain with the areas identified as part of the compulsion network highlighted.

Featured Neuroscience Psychology

·February 14, 2026·6 min read

Brain Signal Linked to OCD Compulsions Identified

A newly identified high-frequency brain signal in the frontal cortex appears to drive compulsive behaviors in OCD. In three severe cases, briefly disrupting this activity through targeted deep brain stimulation rapidly reduced symptoms, offering hope for more precise and responsive treatments.

Featured Neuroscience

·November 17, 2025·6 min read

Brain’s Hidden Inference Engine Revealed

A new study identifies the orbitofrontal cortex (OFC) as a crucial brain region for inference-making, allowing animals to interpret hidden states in changing environments. Researchers trained rats to wait for water rewards that varied in predictable but concealed patterns, showing they adjusted their behavior based on inferred environmental richness.

Featured Neuroscience

·October 9, 2025·8 min read

Brain Cells That Thrive on Uncertainty Help Us Adapt and Learn

Scientists have discovered a group of brain cells in the orbitofrontal cortex that become more active when outcomes are uncertain, revealing how the brain adapts and learns from unpredictable situations. These neurons—found in both rats and humans—help balance flexibility and precision in decision-making, particularly when rewards are inconsistent.

Auditory Neuroscience Featured Neuroscience

·July 11, 2024·5 min read

Brain Region Helps Tune Our Hearing to Focus on Important Sounds

A new study uncovers how the orbitofrontal cortex (OFC) aids the auditory cortex in adapting to different hearing contexts. Researchers found that the OFC sends signals to the auditory cortex to help switch between passive and active listening. This discovery enhances our understanding of how the brain filters and reacts to sounds, with implications for treating neurodevelopmental disorders. The findings highlight the OFC's crucial role in managing auditory attention.

Featured Neuroscience Psychology

·June 13, 2024·6 min read

Study Links Brain Region to Paranoia

Researchers discovered that a specific brain region, the mediodorsal thalamus, may provoke feelings of paranoia. By aligning data from studies on monkeys and humans, they found that lesions in this brain region led to erratic behavior and increased perceptions of environmental volatility.

This shows different brain areas highlighted

Featured Neuroscience

·April 20, 2022·5 min read

Explore or Exploit: How Our Brains Make Choices

Study explores brain activity in primates and humans when presented with a choice between one option that maximizes information and another which prioritizes reward during decision making.

This is a drawing of a mouse on a sail boat

Featured Neuroscience

·October 28, 2021·5 min read

The Goal in Mind: Brain’s Internal Goal Map Helps Animals Precisely Navigate to Chosen Destination

Study reveals a specific neural code for spatial goals, providing evidence for the brain's goal map that guides us to a remote location over space and time.

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orbitofrontal cortex

Brain Activity Predicts Risky Choices Half a Second Before They Are Made

The Neural Signal of Curiosity and Information Value

3-Region Neural Circuit Required for Sleep Memory

Dual Brain Circuits Drive Habit Formation

Causal Network Mapping Isolates Core Brain Circuits of OCD

Brain Signal Linked to OCD Compulsions Identified

Brain’s Hidden Inference Engine Revealed

Brain Cells That Thrive on Uncertainty Help Us Adapt and Learn

Brain Region Helps Tune Our Hearing to Focus on Important Sounds

Study Links Brain Region to Paranoia

Explore or Exploit: How Our Brains Make Choices

The Goal in Mind: Brain’s Internal Goal Map Helps Animals Precisely Navigate to Chosen Destination

Why Cannabis Can Suddenly Trigger Panic

Can an AI Ever Truly Be “Conscious” in the Eyes of Humans?

Comparing Current Appearance to Past Selves Harms Body Image

Optical Illusion Exposes Blind Spot in AI Vision

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