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Summary: White matter tracts show increasing maturation with age from the back to the front of the brain. The maturations begin as a child reaches 9-12 years of age. The maturity correlates with a critical and formative period of development.
Source: Children’s Hospital of Los Angeles
In a first-of-its-kind study, Children’s Hospital Los Angeles researchers piece together a road map of typical brain development in children during a critical window of maturation. The study shows how a “wave of brain maturation” directly underlies important social and behavioral changes children develop during the transition from childhood to adolescence.
As children mature, many aspects of their lives shift in preparation for adulthood. Academic and social environments intensify during this time, requiring increasing mastery of thoughts, emotions, and behavioral control. Very little is known about what is going on neurologically during this important transition. A group of researchers at CHLA examined anatomical and behavioral changes during the finite window of neurological development in a group of 9-12 year old children. A more detailed understanding of typical brain development could give scientists and clinicians a better framework to help care for children who may be developing atypically or facing developmental challenges.
“We know that children are growing substantially in their ability to self-regulate during this time,” says Mary Baron Nelson, PhD, RN, the first author on this publication. “Among many other changes, their attention spans are expanding and they are learning social norms such as gauging appropriate responses or behaviors.” Because these are cognitive processes, the research group hypothesized that measurable changes could be occurring in brain structure and function. This is precisely what they found.
The team of scientists, led by Bradley Peterson, MD, of the Institute for the Developing Mind at CHLA, examined anatomical, chemical, and neuropsychological measures to determine what changes could be occurring in a group of 234 healthy children, aged 9-12 years. “We used brain imaging, measured multiple chemicals and metabolites, and took cognitive and neuropsychological scores,” says Dr. Baron Nelson.
Using imaging and measuring brain metabolites, the group observed what Dr. Baron Nelson refers to as a “wave of maturation” sweeping through the brain. White matter tracts – the pathways in the brain that transmit information – showed increasing maturation with age from the back to the front of the brain. This is expected, as the frontal lobes are not fully formed until an individual is in his or her late twenties. The frontal lobes mediate executive function – major planning of complex decisions and actions. But perhaps less expected is that so many of these changes begin to occur so early on. The findings in the study show that this maturation is largely beginning during years 9-12. This brain maturity correlates with a critical and formative period of time: children are undergoing rapid, neurological maturity at the same time that they are facing difficult social and academic decisions.
As a child grows, he or she becomes more able to control impulses and process complex concepts. In support of this observation the group discovered increasing scores on tasks that measured these skills. But how were these children able to have more impulse control and make more complex decisions? The group analyzed the data and were able to determine that anatomical and metabolic changes occurring during this window of development are responsible for this increase in abilities.
“We’ve learned that this is not a wait-and-see period of time,” says Dr. Baron Nelson. “Dynamic changes are happening here and this gives us a real opportunity for intervention. We can help shape these kids as they grow.”
Authors on this study include Children’s Hospital Los Angeles scientists and clinicians Sharon O’Neil, Jessica Wisnowski, Danielle Hart, Siddhant Sawardekar, Ravi Bansal, and senior author Dr. Peterson. Other authors include: Virginia Rauh, Frederica Perera, Howard Andrews, Lori Hoepner, Wanda Garcia, and Molly Algermissen.
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Source: Children’s Hospital of Los Angeles Media Contacts: Melinda Smith – Children’s Hospital of Los Angeles Image Source: The image is in the public domain.
Original Research: CLosed access “Maturation of Brain Microstructure and Metabolism Associates with Increased Capacity for Self-Regulation during the Transition from Childhood to Adolescence”. Mary Baron Nelson, Sharon H. O’Neil, Jessica L. Wisnowski, Danielle Hart, Siddhant Sawardekar, Virginia Rauh, Frederica Perera, Howard F. Andrews, Lori A. Hoepner, Wanda Garcia, Molly Algermissen, Ravi Bansal and Bradley S. Peterson. Journal of Neuroscience doi:10.1523/JNEUROSCI.2422-18.2019.
Maturation of Brain Microstructure and Metabolism Associates with Increased Capacity for Self-Regulation during the Transition from Childhood to Adolescence
Children ages 9-12 years face increasing social and academic expectations that require mastery of their thoughts, emotions, and behavior. Little is known about the development of neural pathways integral to these improving capacities during the transition from childhood to adolescence. Among 234 healthy, inner-city male and female youth (species homo sapiens) 9-12 years of age followed by the Columbia Center for Children’s Environmental Health (CCCEH), we acquired Diffusion Tensor Imaging (DTI), Multiplanar Chemical Shift Imaging (MPCSI), and cognitive measures requiring self-regulation. We found that increasing age was associated with increased fractional anisotropy (FA) and decreased apparent diffusion coefficient (ADC), most prominently in the frontal and cingulate cortices, striatum, thalamus, deep white matter, and cerebellum. Additionally, we found increasing age was associated with increased N-Acetyl-L-aspartate (NAA) in the anterior cingulate and insular cortices, and decreased NAA in posterior cingulate and parietal cortices. Age-associated changes in microstructure and neurometabolite concentrations partially mediated age-related improvements in performance on executive function tests. Taken together, these findings suggest that maturation of key regions within cortico-striatal-thalamo-cortical (CSTC) circuits subserve the emergence of improved self-regulatory capacities during the transition from childhood to adolescence.
Few imaging studies of normal brain development have focused on a population of inner-city, racial/ethnic minority youth during the transition from childhood to adolescence, a period when self-regulatory capacities rapidly improve. We used DTI and MPCSI to provide unique windows into brain maturation during this developmental epoch, assessing its mediating influences on age-related improvement in performance on self-regulatory tasks. Our findings suggest that rapid maturation of cortico-striato-thalamo-cortical (CSTC) circuits, represented as progressive white matter maturation (increasing FA and increasing NAA, Ch, Cr concentrations accompanying advancing age) in frontal regions and related subcortical projections and synaptic pruning (decreasing NAA, Ch, Cr, Glx) in posterior regions, support age-related improvements in executive functioning and self-regulatory capacities in youth 9-12 years of age.
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