synaptic pruning

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synaptic pruning

This shows neurons in the developing brain

Featured Neuroscience Neuroscience Videos Open Neuroscience Articles

·July 22, 2020·5 min read

New Role for White Blood Cells in the Developing Brain

When T helper cells are absent in the brain, microglia remain suspended between the fetal and adult developmental state. Mice lacking brain T cells showed changes in behavior and defective synaptic pruning. The study reveals the critical role T cells play in the development of the brain.

Autism Featured Genetics Neuroscience Open Neuroscience Articles

·April 15, 2020·5 min read

Autism in males linked to defect in brain immune cells and microglia

An over-production of eIF4E impairs microglial cells, hampering their ability to effectively prune synapses and leading to autism-like behaviors in male mouse models of ASD.

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·January 14, 2020·3 min read

Hyperactive immune system gene causes schizophrenia-like changes

Study implicates C4, an immune system gene, in schizophrenia pathogenesis.

This shows a teenage girl with flowers in her hair

Featured Neuroscience

·September 25, 2019·5 min read

Brain anatomy changes with maturation to adolescence

White matter tracts show increasing maturation with age from the back to the front of the brain. The maturations begin as a child reaches 9-12 years of age. The maturity correlates with a critical and formative period of development.

Autism Featured Neuroscience Open Neuroscience Articles

·June 4, 2019·4 min read

Exercise fine-tunes brain’s connections, eases autism spectrum disorder in mouse model

Participating in exercise improved synaptic pruning in mouse models of autism. The study also found microglia dependant synaptic pruning is impaired by maternal inflammation, which has been previously connected to the development of ASD.

Featured Neuroscience Psychology

·February 4, 2019·5 min read

Excess Immune Pruning of Synapses in Neural Cells Derived From Patients with Schizophrenia

Researchers have directly observed excessive synaptic pruning in cells derived from people with schizophrenia.

Featured Genetics Neurology Neuroscience Psychology

·April 17, 2018·2 min read

Brain Development Influenced by Immune System

A new study provides further evidence for immune system activation during pregnancy and disruptions in brain development. Many adult diseases, researchers say, may originate during fetal development.

Featured Neuroscience Open Neuroscience Articles

·March 26, 2018·3 min read

Captured on Film For the First Time: Microglia Nibbling on Synapses

A new electronic microscopy study has captured microglia perform their role in synaptic pruning.

Featured Neuroscience Psychology

·January 4, 2018·3 min read

Brain’s Immune System May Be Key to Better Treatments for Psychiatric Disorders

Researchers investigate how synaptic pruning occurs during development in hopes of discovering how neurodevelopmental and psychiatric disorders occur.

Featured Neuroscience Open Neuroscience Articles

·November 30, 2017·4 min read

Helping the Brain Prune Bad Habits

Emory researchers report a drug approved in Japan for stroke, can help to stimulate neural pruning and help reduce habit driven behaviors in mice.

Featured Neurology Neuroscience Psychology

·November 5, 2017·4 min read

Why Our Brains Need Sleep, and What Happens If We Don’t Get Enough

From consolidating memories to cleaning out toxins in the brain that accumulate during waking hours, researchers explore why sleep is so important and what happens when we don't get enough.

Electrophysiology Featured Neuroscience Open Neuroscience Articles

·February 3, 2017·4 min read

Brain Plasticity: How Adult Born Neurons Get Wired

Researchers report adult neurogenesis not only helps increase the number of cells in a neural network, it also promotes plasticity in the existing network. Additionally, they have identified the role the Bax gene plays in synaptic pruning.

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