Summary: Neuroimaging reveals a significantly diminished response in the ventromedial prefrontal cortex in children on the autism spectrum. The findings could be used as a biomarker for diagnosing ASD. Source: Wake Forest Baptist Medical Center Scientists at Wake Forest School of Medicine have taken the first step in developing an objective, brain-based test to diagnose autism. Using functional magnetic resonance imaging (fMRI), the team was able to measure the response of autistic children to different environmental cues by imaging a specific part of the brain involved in assigning value to social interactions. Findings from the study are published in the current online edition of the journal Biological Psychology. “Right now, a two- to four-hour session by a qualified clinician is required to diagnose autism, and ultimately it is a subjective assessment based on their experience,” said the study’s principal investigator, Kenneth Kishida, Ph.D., assistant professor of physiology and pharmacology at Wake Forest School of Medicine, part of Wake Forest Baptist Health. “Our test would be a rapid, objective measurement of the brain to determine if the child responds normally to social stimulus versus non-social stimulus, in essence, a biomarker for autism.” Autism spectrum disorder (ASD) is a developmental disorder that affects communication and interaction with other people. The National Institutes of Health estimates that 1 in 60 children in the United States is autistic. In the study, the team led by Kishida and P. Read Montague, Ph.D., of Virginia Tech, tested the responsiveness of the brain’s ventral medial prefrontal cortex (vmPFC) to visual cues that represented highly-valued social interaction in children diagnosed with ASD compared to typically developing (TD) children. The study included 40 participants ranging in age from 6 to18; 12 had ASD and 28 were TD. First, the study participants were scanned in an fMRI while viewing eight images of either people or objects, each one multiple times. Included in each set of images were two self-selected pictures of a favorite person and object from each participant. The other six were standardized images of three faces and three objects, each representing pleasant, neutral or unpleasant aspects from a database widely used in psychological experiments. After completing the 12- to 15-minute MRI scan, the children viewed the same set of images on a computer screen and ranked them in order from pleasant to unpleasant with a self-assessing sliding scale. In addition, pairs of images were viewed and ranked as to which one they liked better. According to the study, the average response of the vmPFC was significantly lower in the ASD group than in the TD group. Using images as a single stimulus to capture 30 seconds of fMRI data was sufficient to differentiate the ASD and TD groups, Kishida said. “How the brain responded to these pictures is consistent with our hypothesis that the brains of children with autism do not encode the value of social exchange in the same way as typically developing children,” he said. “Based on our study, we envision a test for autism in which a child could simply get into a scanner, be shown a set of pictures and within 30 seconds have an objective measurement that indicates if their brain responds normally to social stimulus and non-social stimuli.” He added that this approach could also help scientists better understand the brain mechanisms involved in autism disorder as a whole as well as the many variations on the disorder’s spectrum. Top left: In ASD kids, VMPFC (yellow) activates normally to single presentation of favorite objects Top right: In ASD kids, VMPFC (missing yellow) does not activate normally to single presentation of favorite faces Bottom left and right: In TD kids, VMPFC (yellow) activates normally to single presentation of favorite faces and objects. The image is credited to Wake Forest Baptist Health. Kishida’s team plans to do follow-up studies to identify which additional areas of the brain are involved in the different facets of the disorder to help personalize treatments for patients.See alsoFeaturedNeuroscience·April 13, 2020Remdesivir effective against a key enzyme of coronavirus that causes COVID-19 Funding: This work was funded by a Wellcome Trust Principal Research Fellowship, the Kane Family Foundation, Autism Speaks, the Charles A. Dana Foundation and the National Institutes of Health RO1 DA11723, RO1 MH085496, T32 NS43124 and UL1TR001420-KL2. [divider]About this neuroscience research article[/divider] Source: Wake Forest Baptist Medical Center Media Contacts: Marguerite Beck – Wake Forest Baptist Medical Center Image Source: The image is credited to Wake Forest Baptist Health. Original Research: Open access “Diminished single-stimulus response in vmPFC to favorite people in children diagnosed with Autism Spectrum Disorder”. Kenneth T. Kishida et al. Biological Psychology. doi:10.1016/j.biopsycho.2019.04.009 Abstract Diminished single-stimulus response in vmPFC to favorite people in children diagnosed with Autism Spectrum Disorder From an early age, individuals with autism spectrum disorder (ASD) spend less time engaged in social interaction compared to typically developing peers (TD). One reason behind this behavior may be that the brains of children diagnosed with ASD do not attribute enough value to potential social exchanges as compared to the brains of typically developing children; thus, potential social exchanges are avoided because other environmental stimuli are more highly valued by default. Neurobiological investigations into the mechanisms underlying value-based decision-making has shown that the ventral medial prefrontal cortex (vmPFC) is critical for encoding the expected outcome value of different actions corresponding to distinct environmental cues. Here, we tested the hypothesis that the responsiveness of the vmPFC in children diagnosed with ASD (compared to TD controls) is diminished for visual cues that represent highly valued social interaction. Using a passive picture viewing task and functional magnetic resonance imaging (fMRI) we measured the response of an a priori defined region of interest in the vmPFC in children diagnosed with ASD and an age-matched TD cohort. We show that the average response of the vmPFC is significantly diminished in the ASD group. Further, we demonstrate that a single-stimulus and less than 30 s of fMRI data are sufficient to differentiate the ASD and TD cohorts. These findings are consistent with the hypothesis that the brains of children with ASD do not encode the value of social exchange in the same manner as TD children. The latter finding suggests the possibility of utilizing single-stimulus fMRI as a potential biologically based diagnostic tool to augment traditional clinical approaches. 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