Summary: Two new studies from researchers at USC provide fresh insight into Alzheimer’s risks. Researchers say attending college can stave off dementia and help retain memories in old age. Additionally, researchers report reducing diabetes and hypertension after 50 could increase longevity in people with Alzheimer’s disease.
Education gives people an edge in their later years, helping them to keep dementia at bay and their memories intact, a new USC-led study has found.
“This association between the increase in college attainment and the decline in dementia prevalence is good news for people who have completed some higher education or earned a degree, but what does it mean for people who are less educated?” said Eileen M. Crimmins, the study’s lead author and a University Professor at the USC Leonard Davis School of Gerontology. “They are more likely to develop dementia, and live longer with it.”
The study is one of two by USC researchers published on April 16 in a special, dementia-focused supplement of The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences.
The second USC study appearing in the supplement, led by Julie Zissimopoulos of the USC Schaeffer Center for Health Policy and Economics, explored how dementia would be impacted if other chronic diseases associated with increased risk of dementia were addressed; for example, if the onset of diabetes or hypertension after age 50 was reduced by half.
Such a feat would extend people’s lives by a year and improve their overall health, Zissimopoulos, Crimmins and their co-authors found. However, those improvements would come with a significant tradeoff: more people aged 65 and over would live with dementia and for a longer period of time.
“Reducing onset of hypertension and diabetes at middle and older ages improved the health of these adults but also extended their lives. That in turn increased their overall risk of dementia and ultimately increased the number of individuals living with dementia at older ages,” said Zissimopoulos, an associate professor and vice dean at the USC Price School of Public Policy.
The journal’s special supplement stems from a May 2017 workshop that was funded by the National Institute on Aging to increase understanding of dementia trends.
Educational differences with dementia onset
The study examining the association between educational attainment and dementia utilized data on cognitive ability for Americans 65 years and older from the 2000 and 2010 Health and Retirement Study.
The analysis was based on a sample of 10,374 participants in 2000 and 9,995 in 2010 who were 65 and older. The average age of the sample was about 75 years old. The nationally representative survey checks cognitive status through a series of questions and interviewer observations. Mortality data were from the U.S. National Vital Statistics.
The sample was divided into four categories for educational attainment: those who did not complete high school, those with a high school degree, those with some college, and those who completed a college degree or more.
Life expectancy with healthy cognition increased for people with more education between 2000 and 2010. The lifespan with good cognition of men and women 65 and over who had graduated from college increased by an average of 1.51 years and 1.79 years respectively. The increase in lifespan with good cognition was much smaller among those with the least education — 0.66 years for men and 0.27 years for women.
Healthy cognition characterized most of the people with at least a college education into their late 80s, the study found. People who did not complete high school had good cognition up until their 70s.
“Higher education status appears to provide lifelong cognitive benefits from both its effect on cognitive functioning and its effect on longer life,” the researchers wrote.
Focus efforts on delaying dementia
Scientists and pharmaceutical companies for many years have been working on treatments for Alzheimer’s disease and dementia, but so far, there is no cure. They are now turning their focus to these questions: Can you delay the onset of dementia? Can you do so indirectly, by targeting a chronic age-related disease?
For this study, Zissimopoulos and a team of researchers utilized seven waves of data from years 2000 to 2012 on a sample of 27,734 people 51 and older from the national Health and Retirement Survey, which assesses health status and disease over the lifecycle. The data were utilized to model how health evolves at middle and older ages accounting for the interdependent associations of risk factors for dementia and the impact of these risk factors on both morbidity and mortality.
The researchers employed a dynamic microsimulation model, the Future Elderly Model, developed by the Roybal Center for Health Policy Simulation at the USC Schaeffer Center, and analyzed how a series of scenarios would affect the health, longevity and healthy cognitive lifespan of a cohort of people aged 51 and 52 over their lifecycle. The scenarios included the status quo of no health improvements, reducing incidence of hypertension by half, eliminating hypertension after age 50, zeroing out hypertension before age 50, reducing incidence of diabetes by half. They compared these health improvement scenarios to a scenario with a hypothetical new treatment that delays dementia by two years. Many researchers and institutions are working to develop such a treatment.
They found that while reductions in hypertension and diabetes would improve health and longevity, they would increase the number of years living with dementia. The simulation revealed, for instance, that curing hypertension would increase the average number of years of living with dementia assuming survival to age 65, to 3.37 years, compared to the status quo of 2.94 years.
“We found that only treatments that delay dementia onset both increase life expectancy and reduce the number of years living with dementia,” Zissimopoulos said.
An innovation in treatment that delays dementia onset would, across the entire cohort, reduce the number of years living with dementia compared to the status quo by about one-half a year.
Zissimopoulos and Crimmins are among more than 70 researchers at USC focusing their research on Alzheimer’s disease and dementia, which affect an estimated 5 million Americans. Alzheimer’s disease alone costs an estimated $236 billion a year in health care services.
USC researchers across a range of disciplines are examining the health and economic effects and implications of the disease. Many of them are working to develop the foundation of a future treatment.
In the past decade, the National Institute on Aging has nearly doubled its investment in USC research. The investments include an Alzheimer Disease Research Center.
Funding: The study led by Crimmins on the education-dementia link was supported by NIA grants P30 AG17265 for the USC/UCLA Center on Biodemography and Population Health, R24AG045061 and U01 AG009740 , which supported the collection of data for the national Health and Retirement Study, as well as by a National Institute of Child Health and Human Development grant, 5 R24 HD042849.
Co-authors were Yasuhiko Saito of Nihon University, Japan; Jung Ki Kim and Yuan Zhang of USC, Isaac Sasson of Tel Aviv University, Israel; and Mark D. Hayward of the University of Texas at Austin.
Zissimopoulos’s study utilizing the Family Elderly Model was supported by NIA grants 5P30AG024968, P30G017265 and P30AG012846.
Other co-authors on her study of delaying dementia onset were Bryan Tysinger and Patricia St. Clair of the Roybal Center for Health Policy Simulation at the USC Schaeffer Center, as well as Crimmins.
Source: Emily F. Gersema – USC
Publisher: Organized by NeuroscienceNews.com.
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Original Research: Abstract for “Educational Differences in the Prevalence of Dementia and Life Expectancy with Dementia: Changes from 2000 to 2010” by Eileen M Crimmins, PhD Yasuhiko Saito, PhD; Jung Ki Kim, PhD; Yuan S Zhang, MS; Isaac Sasson, PhD; and Mark D Hayward, PhD in The Journals of Gerontology: Series B Psychological Sciences and Social Sciences. Published April 16 2018.
Abstract for “The Impact of Changes in Population Health and Mortality on Future Prevalence of Alzheimer’s Disease and Other Dementias in the United States” by Julie M Zissimopoulos, PhD; Bryan C Tysinger, MS; Patricia A St.Clair, ScB; and Eileen M Crimmins, PhD in The Journals of Gerontology: Series B Psychological Sciences and Social Sciences. Published April 16 2018.
Educational Differences in the Prevalence of Dementia and Life Expectancy with Dementia: Changes from 2000 to 2010
This article provides the first estimates of educational differences in age-specific prevalence, and changes in prevalence over time, of dementia by education levels in the United States. It also provides information on life expectancy, and changes in life expectancy, with dementia and cognitively healthy life for educational groups.
Data on cognition from the 2000 and 2010 Health and Retirement Study are used to classify respondents as having dementia, cognitive impairment without dementia (CIND), or being cognitively intact. Vital statistics data are used to estimate life tables for education groups and the Sullivan method is used to estimate life expectancy by cognitive state.
People with more education have lower prevalence of dementia, more years of cognitively healthy life, and fewer years with dementia. Years spent in good cognition increased for most sex-education groups and, conversely, years spent with dementia decreased for some. Mortality reduction was the most important factor in increasing cognitively healthy life. Change in the distribution of educational attainment has played a major role in the reduction of life with dementia in the overall population.
Differences in the burden of cognitive loss by education point to the significant cost of low social status both to individuals and to society.
The Impact of Changes in Population Health and Mortality on Future Prevalence of Alzheimer’s Disease and Other Dementias in the United States
We assessed potential benefits for older Americans of reducing risk factors associated with dementia.
A dynamic simulation model tracked a national cohort of persons 51 and 52 years of age to project dementia onset and mortality in risk reduction scenarios for diabetes, hypertension, and dementia.
We found reducing incidence of diabetes by 50% did not reduce number of years a person ages 51 or 52 lived with dementia and increased the population ages 65 and older in 2040 with dementia by about 115,000. Eliminating hypertension at middle and older ages increased life expectancy conditional on survival to age 65 by almost 1 year, however, it increased years living with dementia. Innovation in treatments that delay onset of dementia by 2 years increased longevity, reduced years with dementia, and decreased the population ages 65 and older in 2040 with dementia by 2.2 million.
Prevention of chronic disease may generate health and longevity benefits but does not reduce burden of dementia. A focus on treatments that provide even short delays in onset of dementia can have immediate impacts on longevity and quality of life and reduce the number of Americans with dementia over the next decades.