Study Reveals Source of Remarkable Memory of “Superagers”

Summary: The structure of SuperAgers’ brains and the connectivity of their neural networks more closely resembles the brains of younger adults, a neuroimaging study reveals.

Source: Mass General

As we age, our brains typically undergo a slow process of atrophy, causing less robust communication between various brain regions, which leads to declining memory and other cognitive functions. But a rare group of older individuals called “superagers” have been shown to learn and recall novel information as well as a 25-year-old. Investigators from Massachusetts General Hospital (MGH) have now identified the brain activity that underlies superagers’ superior memory.

“This is the first time we have images of the function of superagers’ brains as they actively learn and remember new information,” says Alexandra Touroutoglou, PhD, director of Imaging Operations at MGH’s Frontotemporal Disorders Unit and senior author of the paper published in Cerebral Cortex.

In 2016, Touroutoglou and her fellow researchers identified a group of adults older than 65 with remarkable performance on memory tests. The superagers are participants in an ongoing longitudinal study of aging at MGH led by Bradford Dickerson, MD, director of the Frontotemporal Disorders Unit at MGH, and Lisa Feldman Barrett, PhD, a research scientist in Psychiatry at MGH.

“Using MRI, we found that the structure of superagers’ brains and the connectivity of their neural networks more closely resemble the brains of young adults; superagers had avoided the brain atrophy typically seen in older adults,” says Touroutoglou.

In the new study, the investigators gave 40 adults with a mean age of 67 a very challenging memory test while their brains were imaged using functional magnetic resonance imaging (fMRI), which, unlike typical MRI, shows the activity of different brain areas during tasks. Forty-one young adults (mean age of 25) also took the same memory test while their brains were imaged.

The participants first viewed 80 pictures of faces or scenes that were each paired with an adjective, such as a cityscape paired with the word “industrial” or a male face paired with the word “average.”

Their first task was to determine whether the word matched the image, a process called encoding.

After 10 minutes, participants were presented with the 80 image-word pairs they had just learned, an additional 40 pairs of new words and images, and 40 rearranged pairs consisting of words and images they had previously seen.

Their second task was to recall whether they had previously seen each specific word-picture pair, or whether they were looking at a new or rearranged pair.

While the participants were in the scanner, the researchers paid close attention to the visual cortex, which is the area of the brain that processes what you see and is particularly sensitive to aging.

“In the visual cortex, there are populations of neurons that are selectively involved in processing different categories of images, such as faces, houses or scenes,” says lead author Yuta Katsumi, PhD, a postdoctoral fellow in Psychiatry at MGH.

“This selective function of each group of neurons makes them more efficient at processing what you see and creating a distinct memory of those images, which can then easily be retrieved.”

During aging, this selectivity, called neural differentiation, diminishes and the group of neurons that once responded primarily to faces now activates for other images.

The brain now has difficulty creating unique neural activation patterns for different types of images, which means it is making less distinctive mental representations of what the person is seeing. That’s one reason older individuals have trouble remembering when they may have seen a television show, read an article, or eaten a specific meal.

But in the fMRI study, the superagers’ memory performance was indistinguishable from the 25-year-olds’, and their brains’ visual cortex maintained youthful activity patterns.

“The superagers had maintained the same high level of neural differentiation, or selectivity, as a young adult,” says Katsumi. “Their brains enabled them to create distinct representations of the different categories of visual information so that they could accurately remember the image-word pairs.”

This shows an older gentleman
While the participants were in the scanner, the researchers paid close attention to the visual cortex, which is the area of the brain that processes what you see and is particularly sensitive to aging. Image is in the public domain

An important question that researchers still must answer is whether “superagers’ brains were always more efficient than their peers, or whether, over time, they developed mechanisms to compensate for the decline of the aging brain,” says Touroutoglou.

Previous studies have shown that training can increase the selectivity of brain regions, which may be a potential intervention to delay or prevent the decline in neural differentiation in normal aging adults and make their brains more like those of superagers.

Currently, the researchers are conducting a clinical trial to evaluate whether noninvasive electromagnetic stimulation, which delivers an electrical current to targeted areas of the brain, can improve memory in older adults.

The researchers also plan to study different brain regions to further understand how superagers learn and remember, and they will examine lifestyle and other factors that might contribute to superagers’ amazing memory.

Funding: Major funding for this study was provided by the National Institute on Aging.

Touroutoglou is an assistant professor of Neurology at Harvard Medical School (HMS). Dickerson is professor of Neurology at HMS. Barrett is distinguished professor of Psychology at Northeastern University. The other co-author is Joseph Andreano, PhD, an investigator in the Department of Psychiatry at MGH and an instructor of Psychiatry at HMS.

About this aging and memory research news

Source: Mass General
Contact: Marcela Quintanilla Dieck – Mass General
Image: The image is in the public domain

Original Research: Open access.
Greater Neural Differentiation in the Ventral Visual Cortex Is Associated with Youthful Memory in Superaging” by Alexandra Touroutoglou et al. Cerebral Cortex


Abstract

Greater Neural Differentiation in the Ventral Visual Cortex Is Associated with Youthful Memory in Superaging

Superagers are older adults who maintain youthful memory despite advanced age. Previous studies showed that superagers exhibit greater structural and intrinsic functional brain integrity, which contribute to their youthful memory. However, no studies, to date, have examined brain activity as superagers learn and remember novel information.

Here, we analyzed functional magnetic resonance imaging data collected from 41 young and 40 older adults while they performed a paired associate visual recognition memory task.

Superaging was defined as youthful performance on the long delay free recall of the California Verbal Learning Test. We assessed the fidelity of neural representations as participants encoded and later retrieved a series of word stimuli paired with a face or a scene image.

Superagers, like young adults, exhibited more distinct neural representations in the fusiform gyrus and parahippocampal gyrus while viewing visual stimuli belonging to different categories (greater neural differentiation) and more similar category representations between encoding and retrieval (greater neural reinstatement), compared with typical older adults.

Greater neural differentiation and reinstatement were associated with superior memory performance in all older adults. Given that the fidelity of cortical sensory processing depends on neural plasticity and is trainable, these mechanisms may be potential biom

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