Summary: A new study sheds additional light on how the brain consolidates memory during sleep. Researchers report rapid fluctuations in gamma band activity in the hippocampus during nREM sleep helps facilitate memory reactivation.
Researchers from Ruhr-Universität Bochum and the University of Bonn have investigated which activity patterns occur in the brain when people remember or forget things. They were interested in how the brain replays and stores during sleep what it had learned before. The team recorded the brain activity of epilepsy patients who had electrodes implanted into their brain for the purpose of surgical planning. One result: During sleep, the brain even reactivates memory traces that it can no longer remember later on.
Dr. Hui Zhang and Professor Nikolai Axmacher from the Department of Neuropsychology in Bochum describe the results together with Associate Professor Dr. Juergen Fell from the Department of Epileptology in Bonn in the journal Nature Communications, published on 5 October 2018.
Learning task before afternoon nap
For the experiment, the test participants were given a series of pictures to memorise. They then took an afternoon nap. When looking at a picture, the activity in the brain shows a pattern that differs somewhat from picture to picture. The researchers were able to measure these differences in high-frequency activity fluctuations – called gamma band activity. They analysed brain activity not only during the learning task, but also during sleep. They then tested which images the participants could remember after sleep and which they could not.
Brain reactivates memory traces
The gamma band activity that was typical of certain motifs occurred not only when looking at the images, but also during sleep. The brain reactivated the activity patterns – both for images the participants later remembered and for those they later forgot. “The forgotten images do not simply disappear from the brain,” concludes Hui Zhang.
Two types of brain activity decisive
The decisive factor in whether an image was forgotten or retained was not the reactivation of the image-specific gamma band activity, but the activity in a brain region that is important for memory: the hippocampus. This region shows extremely rapid fluctuations in activity, called ripples. A picture was only recalled later on when the reactivation occurred at the same time as the ripples in the hippocampus. This phenomenon only occurred during certain sleep phases, but not when the participants were awake.
Specifically, whether an image is remembered or not depended on another factor, namely how detailed the image was processed in the brain. The researchers differentiated the gamma band activity measured when viewing the images into a superficial and a deep processing stage. The superficial processing took place during the first half second after the presentation of the image, the deeper processing after that. Only when the gamma band activity from the deep processing phase was reactivated during the ripples did the participants later remember the image. If the activity from the early processing phase was reactivated, the image was forgotten.
Funding: German Research Foundation funded this study.
Source: Nikolai Axmacher – RUB
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: Open access research for “Electrophysiological mechanisms of human memory consolidation” by Hui Zhang, Juergen Fell & Nikolai Axmacher in Nature Communications. Published October 5 2018.
Electrophysiological mechanisms of human memory consolidation
Consolidation stabilizes memory traces after initial encoding. Rodent studies suggest that memory consolidation depends on replay of stimulus-specific activity patterns during fast hippocampal “ripple” oscillations. Here, we measured replay in intracranial electroencephalography recordings in human epilepsy patients, and related replay to ripples. Stimulus-specific activity was identified using representational similarity analysis and then tracked during waking rest and sleep after encoding. Stimulus-specific gamma (30–90 Hz) activity during early (100–500 ms) and late (500–1200 ms) encoding is spontaneously reactivated during waking state and sleep, independent of later memory. Ripples during nREM sleep, but not during waking state, trigger replay of activity from the late time window specifically for remembered items. Ripple-triggered replay of activity from the early time window during nREM sleep is enhanced for forgotten items. These results provide the first electrophysiological evidence for replay related to memory consolidation in humans, and point to a prominent role of nREM ripple-triggered replay in consolidation processes.