Premature Brains Develop Differently in Boys and Girls

Summary: A new study reports the brains of baby boys born prematurely are affected differently and more severely than premature females.

Source: Springer.

Brains of baby boys born prematurely are affected differently and more severely than premature infant girls’ brains. This is according to a study published in the Springer Nature-branded journal Pediatric Research. Lead authors Amanda Benavides and Peg Nopoulos of the University of Iowa in the US used magnetic resonance imaging (MRI) scans as part of an ongoing study on premature babies to examine how the brains of baby boys and girls changed and developed.

The researchers took high-quality MRI scans of the brains of 33 infants whose ages were corrected to that of one year. The sample included babies who were carried to full term (at least 38 weeks) and preterm (less than 37 weeks). The scans were analyzed in conjunction with information gathered from questionnaires completed by the infants’ mothers and other data collected when they were born.

“The window between birth and one year of age is the most important time in terms of brain development. Therefore studying the brain during this period is important to better understand how the premature brain develops,” explains Benavides.

Brain measurements taken from the MRIs showed that even at this very young age, there are major sex differences in the structure of the brain, and these are independent of the effects of prematurity. Brain tissue is divided into cerebral gray matter which includes regions of the brain that influence muscle control, the senses, memory, speech and emotion, and cerebral white matter which helps to link different parts of grey matter to each other. While boys’ brains were overall larger in terms of volume, girls had proportionately larger volumes of gray matter and boys had proportionately larger volumes of white matter. These same sex differences are seen in children and adults, and therefore document how early in life these differences are seen.

In regard to the effects of prematurity, the researchers found that the earlier a baby was born, the smaller the overall cerebral volume. However, the effect of prematurity on the specific tissues was different depending on a baby’s gestation age in conjunction with its sex. The earlier a baby boy was born, the lower the researchers found his cortex volume (gray matter) to be. The earlier a baby girl was born, the lower was the volume of white matter in her brain. Overall, although the effects of prematurity were seen in both boys and girls, these effects were more severe for boys.

a baby
The researchers took high-quality MRI scans of the brains of 33 infants whose ages were corrected to that of one year. image is in the public domain.

According to the research team, it is well known that male fetuses are more vulnerable to developmental aberration, and that this could lead to other unfavorable outcomes. Findings from the current study now add to this by showing how the brains of baby boys born too early are affected differently to that of baby girls.

“Given this background, it seems likely and even expected that the effects of prematurity on brain development would be more severe in males. The insults to the premature brain incurred within the first few weeks and months of life set the stage for an altered developmental trajectory that plays out throughout the remainder of development and maturation,” says Nopoulos.

About this neuroscience research article

Source: Daryl A Lovell – Springer
Publisher: Organized by
Image Source: image is in the public domain.
Original Research: Abstract for “Sex-specific alterations in preterm brain” by Amanda Benavides, Andrew Metzger, Sasha Tereschenko, Amy Conrad, Edward F. Bell, John Spencer, Shannon Ross-Sheehy, Michael Georgieff, Vince Magnotta & Peg Nopoulos in Pediatric Research. Published September 19 2018.

Cite This Article

[cbtabs][cbtab title=”MLA”]Springer”Premature Brains Develop Differently in Boys and Girls.” NeuroscienceNews. NeuroscienceNews, 19 September 2018.
<>.[/cbtab][cbtab title=”APA”]Springer(2018, September 19). Premature Brains Develop Differently in Boys and Girls. NeuroscienceNews. Retrieved September 19, 2018 from[/cbtab][cbtab title=”Chicago”]Springer”Premature Brains Develop Differently in Boys and Girls.” (accessed September 19, 2018).[/cbtab][/cbtabs]


Sex-specific alterations in preterm brain

The literature on brain imaging in premature infants is mostly made up of studies that evaluate neonates, yet the most dynamic time of brain development happens from birth to 1 year of age. This study was designed to obtain quantitative brain measures from magnetic resonance imaging scans of infants born prematurely at 12 months of age.

The subject group was designed to capture a wide range of gestational age (GA) from premature to full-term infants. An age-specific atlas generated quantitative brain measures. A regression model was used to predict effects of GA and sex on brain measures.

There was a primary effect of sex on: (1) intracranial volume, males > females; (2) proportional cerebral cortical gray matter (females > males), and (3) cerebral white matter (males > females). GA predicted cerebral volume and cerebral spinal fluid. GA also predicted cortical gray matter in a sex-specific manner with GA having a significant effect on cortical volume in the males, but not in females.

Conclusions and relevance
Sex differences in brain structure are large early in life. GA had sex-specific effects highlighting the importance evaluating sex effects in neurodevelopmental outcomes of premature infants.

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