Summary: A new study reports a mother’s diet during pregnancy may have an effect on the composition of her child’s gut bacteria. The effect, researchers report, may vary by the method of delivery at birth.
Source: Biomed Central.
A mother’s diet during pregnancy may have an effect on the composition of her baby’s gut microbiome – the community of bacteria living in the gut – and the effect may vary by delivery mode, according to study published in the open access journal Microbiome.
Sara Lundgren, lead author of the study said: “Our study demonstrates an association of a readily modifiable factor, maternal diet, with the infant gut microbiome. This knowledge may be key for developing evidence-based dietary recommendations for pregnant and lactating women.”
Lundgren and colleagues at Dartmouth-Hitchcock medical Center, USA found that the gut microbiome in infants six weeks after delivery was composed mostly of Enterobactericeae (~20%), Bifidobacterium (18.6%), Bacteroides (10.44%) and Streptococcus (8.10%).
The authors identified three distinct clusters of microbes in the guts of the 97 babies included in this study that had been vaginally delivered. Cluster 1 was characterized by a high abundance of Bifidobacterium, cluster 2 showed a high abundance of Streptococcus and Clostridium, while cluster 3 had a high abundance of Bacteroides. These clusters were different for the 48 babies delivered by caesarian section, where cluster 1 showed a high abundance of Bifidobacterium, cluster 2 was characterized by high Clostridium but low Streptococcus abundance, and cluster 3 showed a higher abundance of Enterobactericeae.
The authors also observed what appear to be effects of certain aspects of the mothers’ diets on the babies’ gut microbiome. In babies delivered vaginally, the odds of being in cluster 2 were 2.73 times higher for each additional serving of fruit consumed by the mothers per day. Bifidobacterium was found to be decreased in vaginally born infants if mothers ate more fruit, but increased in babies born by caesarian in relation to the mothers’ consumption of red and processed meat. In babies delivered by caesarian section, the odds of being in cluster 2 were 2.36 higher for each additional maternal serving of dairy per day.
Lundgren said: “We analyzed infants delivered vaginally and by cesarean section in separate groups due to our previous knowledge of the transfer of maternal microbiota to the infant that occurs during vaginal delivery, but not with cesarean section delivery. We expected results to differ based on delivery mode, but we were surprised to find that the abundances of some microbes were increased in association with maternal intake of a food group in one delivery mode group, but decreased in the other delivery mode group.”
To shed further light on the mechanisms by which maternal diet may affects children’s health via the gut microbiome the authors used stool samples from 145 infants enrolled in the New Hampshire Birth Cohort Study, a research project that investigates how various factors affect the health of pregnant women and their children. Most infants whose data was used in this study were born vaginally (66.9%) and exclusively breast fed (70.3%) at six weeks of age. Information on the mothers’ diets during pregnancy at 24 to 28 weeks gestation was obtained via food frequency questionnaires.
The authors caution that as their sample only included mothers and infants from Northern New England which has a relatively homogenous population, the generalizability of the findings may be limited. The authors also point out that the effects observed in this study may be due in part to maternal diet during lactation. The observational nature of the study does not allow for conclusions about cause and effect or the directionality of the observed association between maternal diet and the baby gut microbiome.
Source: Anne Korn – Biomed Central
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Original Research: Open access research for “Maternal diet during pregnancy is related with the infant stool microbiome in a delivery mode-dependent manner” by Sara N. Lundgren, Juliette C. Madan, Jennifer A. Emond, Hilary G. Morrison, Brock C. Christensen, Margaret R. Karagas and Anne G. Hoen in Lancet Public Health. Published July 5 2018.
Maternal diet during pregnancy is related with the infant stool microbiome in a delivery mode-dependent manner
The gut microbiome has an important role in infant health and immune development and may be affected by early-life exposures. Maternal diet may influence the infant gut microbiome through vertical transfer of maternal microbes to infants during vaginal delivery and breastfeeding. We aimed to examine the association of maternal diet during pregnancy with the infant gut microbiome 6 weeks post-delivery in mother-infant dyads enrolled in the New Hampshire Birth Cohort Study. Infant stool samples were collected from 145 infants, and maternal prenatal diet was assessed using a food frequency questionnaire. We used targeted sequencing of the 16S rRNA V4-V5 hypervariable region to characterize infant gut microbiota. To account for differences in baseline and trajectories of infant gut microbial profiles, we stratified analyses by delivery mode.
We identified three infant gut microbiome clusters, characterized by increased abundance of Bifidobacterium, Streptococcus and Clostridium, and Bacteroides, respectively, overall and in the vaginally delivered infant stratum. In the analyses stratified to infants born vaginally and adjusted for other potential confounders, maternal fruit intake was associated with infant gut microbial community structure (PERMANOVA, p < 0.05). In multinomial logistic regression analyses, increased fruit intake was associated with an increased odds of belonging to the high Streptococcus/Clostridium group among infants born vaginally (OR (95% CI) = 2.73 (1.36, 5.46)). In infants delivered by Cesarean section, we identified three clusters that differed slightly from vaginally delivered infants, which were characterized by a high abundance of Bifidobacterium, high Clostridium and low Streptococcus and Ruminococcus genera, and high abundance of the family Enterobacteriaceae. Maternal dairy intake was associated with an increased odds of infants belonging to the high Clostridium cluster in infants born by Cesarean section (OR (95% CI) = 2.36 (1.05, 5.30)). Linear models suggested additional associations between maternal diet and infant intestinal microbes in both delivery mode strata.
Our data indicate that maternal diet influences the infant gut microbiome and that these effects differ by delivery mode.