New Target Receptor Discovered in the Fight Against Obesity

Summary: Researchers inject a cold virus into a woman’s brain in an effort to eradicate cancer.

Source: King’s College London.

The team of scientists from King’s College London and Imperial College London tested a high-fat diet, containing a fermentable carbohydrate, and a control diet on mice and looked at the effect on food intake of those with and without the FFAR2 receptor.

The results showed that mice fed the diet containing fermentable carbohydrate were protected against obesity. This protection was lost however, when the FFAR2 receptor was not present. Indeed, those with the receptor showed an increase of 130% in the satiety inducing gut hormone peptide YY, as well as an increased density of cells containing PYY, leading to an increased feeling of fullness.

Lead author of the study, Gavin Bewick from King’s College London said: “Obesity is currently one of the most serious global threats to human health, determined by genetic background, diet, and lifestyle. We know that supplementing your diet with non-digestible carbohydrates reduce appetite and body weight gain, but in this study we demonstrate for the first time the essential role of the FFAR2 receptor in enabling specific dietary constituents to reduce food intake and protect against obesity.

Image shows a cheese burger.

“Obesity is currently one of the most serious global threats to human health, determined by genetic background, diet, and lifestyle.” NeuroscienceNews.com image is for illustrative purposes only.

“With this discovery, we can start to look at whether we can use diet or pharmaceutical means to change the cellular make-up of the gut in order to treat a host of disorders.”

Professor Gary Frost, co-lead author from the Department of Medicine at Imperial said: “This a major step forward in understanding the relationship between diet and appetite regulation. Until a few years ago dietary fibre was a thought of as inert, and having very little effect on physiology. So the fact it actually has a major impact on cells that help control appetite regulation in the colon is amazing.”

He added: “Our challenge now is to translate this into a technology that we can apply to humans. We need to understand how we can use the knowledge and insight gained to develop food systems that are attractive to a large percentage of the population.”

About this obesity research article

Source: Tanya Wood – King’s College London
Image Source: NeuroscienceNews.com image is for illustrative purposes only.
Original Research: Abstract for “Fermentable carbohydrates increase satiety signals” by Claire Greenhill, corresponding authors Gary Frost and Gavin Bewick in Nature Reviews Endocrinology. November 25 2016 doi:10.1038/nrendo.2016.199

Cite This NeuroscienceNews.com Article
King’s College London. “New Target Receptor Discovered in the Fight Against Obesity.” NeuroscienceNews. NeuroscienceNews, 27 November 2016.
<http://neurosciencenews.com/obesity-receptor-target-5608/>.
King’s College London. (2016, November 27). New Target Receptor Discovered in the Fight Against Obesity. NeuroscienceNews. Retrieved November 27, 2016 from http://neurosciencenews.com/obesity-receptor-target-5608/
King’s College London. “New Target Receptor Discovered in the Fight Against Obesity.” http://neurosciencenews.com/obesity-receptor-target-5608/ (accessed November 27, 2016).

Abstract

Fermentable carbohydrates increase satiety signals

Supplementing the diets of rodents and humans with fermentable carbohydrates can reduce appetite and body weight gain; however, the mechanisms underlying this action were not known. Now, a new paper suggests that the effect of these carbohydrates is dependent on free fatty acid receptor 2 (FFAR2).

When the gut microbiota ferments non-digestible carbohydrates, they produce short-chain fatty acids (SCFAs) such as acetate and propionate, which signal via FFAR2. “We hypothesized the mechanism by which fermentable carbohydrates protect against diet-induced obesity.

“Fermentable carbohydrates increase satiety signals” by Claire Greenhill, corresponding authors Gary Frost and Gavin Bewick in Nature Reviews Endocrinology. November 25 2016 doi:10.1038/nrendo.2016.199

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