Alzheimer's disease may be driven by excessive fructose metabolism in the brain. The findings shed light on why diseases, such as diabetes and obesity, are linked to an increased risk of Alzheimer's. Read More
Depression and anxiety have different biochemical links to inflammation and lipid metabolism. Those with depression have greater levels of inflammation and different types and amounts of lipids in their blood compared to those with anxiety. The metabolites associated with depression were linked to the severity of symptoms. Higher levels of lipids associated with depression detected in a person's blood correlated with more severe symptoms. Read More
Neurons can counteract degeneration and promote survival by adapting their metabolism. Read More
The enzyme PHD3 plays a critical role in sensing nutrient availability and regulating the ability of muscles to break down fat. Blocking PHD3 production in mice leads to dramatic improvements in specific measures of fitness. Findings shed light on the key mechanism for how cells metabolize fuel and provide a novel understanding of muscle function and fitness. Read More
Study in rats reveals sex differences may play a key role in the effectiveness of exercise as an appetite regulator. Exercising female rats ate more than those who did not partake in physical activity. The same effect was not seen in males. Read More
Maternal obesity may hinder their child's brain development as soon as the second trimester of pregnancy. High maternal BMI is associated with changes to the child's prefrontal cortex and anterior insula, two brain areas associated with decision making, and behavior. Read More
Suppressing the activity of hypothalamic neurons in mice during REM sleep resulted in a decrease in the amount of food later consumed. The study suggests REM sleep is essential to stabilize food intake. Read More
Beta2-adrenergic receptors in brown fat cells are responsible for stimulating thermogenesis. Read More
Paying attention alters how the brain allocates its limited energy. As the brain uses more energy to process information we attend to, the less energy is supplied to processing outside our field of attention. Read More
Both food timing and the integrity of the internal clock in the liver altered rhythms of metabolism in mice. Almost half of the rhythmic genes are regulated by both the internal clock and when food is ingested. Read More
Artificially inducing peripheral inflammation in mice triggered the sudden onset of delirium-like cognitive dysfunction, and this was mediated by a disturbance in energy metabolism. Read More
Blood samples reveal unique metabolic signatures in over 50% of children on the autism spectrum. Read More
