During vigorous exercise, the body produces large amounts of the hormone GDF15, but the quantity is not sufficient enough to affect behavior or appetite. Read More
Exercise promotes the hypothalamus to release MOTS-c. Mitochondrial encoded MOTS-c interacts with the nuclear genome and regulates both cell metabolism and the stress response. Read More
Better glucose uptake compensates for age-related motor deterioration and extends lifespan in fruitflies. Read More
B. longum APC1472 reduces blood glucose levels and reduces weight gain in mouse models. The bacteria also keep ghrelin, a hormone associated with hunger, and the stress hormone cortisol in check. Read More
Drinking water can suppress the vasopressin hormone receptor, mitigating obesity and metabolic syndrome in mice. Read More
Early childhood trauma has an impact on glucose metabolism and blood composition, which are passed on to the next generation. Read More
The hunger hormone ghrelin doesn't just influence where and when animals eat, it also appears to have an impact on memory. Disrupting signaling of ghrelin to the vagus nerve caused rats to forget they had just eaten, even though the animals remembered they had just had access to food. Findings suggest disrupted ghrelin signaling could negatively impact episodic memory. Read More
While poor sleep can have some impact on metabolism, drinking coffee immediately after waking can harm glucose control. Strong black coffee consumed before breakfast increased blood glucose response to food by 50%. Read More
Alzheimer's disease may be driven by excessive fructose metabolism in the brain. The findings shed light on why diseases, such as diabetes and obesity, are linked to an increased risk of Alzheimer's. Read More
Depression and anxiety have different biochemical links to inflammation and lipid metabolism. Those with depression have greater levels of inflammation and different types and amounts of lipids in their blood compared to those with anxiety. The metabolites associated with depression were linked to the severity of symptoms. Higher levels of lipids associated with depression detected in a person's blood correlated with more severe symptoms. Read More
Neurons can counteract degeneration and promote survival by adapting their metabolism. Read More
The enzyme PHD3 plays a critical role in sensing nutrient availability and regulating the ability of muscles to break down fat. Blocking PHD3 production in mice leads to dramatic improvements in specific measures of fitness. Findings shed light on the key mechanism for how cells metabolize fuel and provide a novel understanding of muscle function and fitness. Read More
