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Pain Neuroscience news articles cover science research about pain receptors, nociceptors, nociception, sensory neurons, somatosensory cortex, chronic pain, acute pain, nocioceptors, musculoskeletal pain, therapies, phantom limb pain and other pain research.

Featured Neuroscience Pain

·September 24, 2024·3 min read

Dopamine Not Essential for Placebo Effect in Pain Relief

New research reveals that dopamine is not directly responsible for the formation of placebo analgesia, contrary to previous beliefs. In a study with 168 participants, altering dopamine levels did not affect positive treatment expectations or pain relief.

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Electrophysiology Featured Neurology Neuroscience Pain

·September 23, 2024·5 min read

How the Brain Integrates Pain Expectations and Reality

New research reveals how the brain combines pain expectations with actual pain intensity, offering insights into the brain's pain integration process. Using fMRI, scientists found that while all brain networks store pain information, only higher-level networks integrate pain expectations and stimuli into a cohesive experience.

Featured Neurology Neuroscience Pain

·September 5, 2024·6 min read

Mindfulness Meditation Reduces Pain More Than Placebo

Mindfulness meditation reduces pain by engaging distinct brain mechanisms, different from the placebo effect. Researchers found that mindfulness meditation was significantly more effective at reducing pain intensity and unpleasantness compared to placebo treatments.

Featured Neurology Neuroscience Pain

·August 30, 2024·3 min read

Morphine’s Pain Relief Mechanism Unveiled

Researchers have uncovered how morphine relieves pain by activating a specific group of neurons in the brain, termed the 'morphine ensemble.' These neurons, located in the rostral ventromedial medulla (RVM), connect to the spinal cord and inhibit pain signaling. Understanding this pathway could help reduce the severe side effects of morphine, such as addiction and overdose. The findings also provide insights into the differences between pain relief and the euphoric effects of morphine.

Featured Neurology Neuroscience Pain

·August 20, 2024·3 min read

Molecule Discovery Could Revolutionize Chronic Pain Treatment

Researchers have identified a natural molecule, phosphatidic acid, that reduces the sensitivity of touch-sensing ion channels, providing a promising new avenue for managing chronic pain. By increasing levels of this molecule, cells become less sensitive to touch, which was confirmed through tests on sensory neurons and in mice. This discovery could lead to more targeted and effective treatments for conditions involving inflammatory pain.

Featured Neurology Neuroscience Pain

·July 13, 2024·5 min read

Brain’s Lymphatic System Plays Role in Migraine Pain

Researchers discovered how the protein CGRP affects the brain's lymphatic system, contributing to migraine pain. Their study reveals that CGRP prevents cerebrospinal fluid from draining, influencing migraine attacks. This finding could lead to new therapeutic strategies for migraines. More research is needed to understand the sex differences in migraine prevalence.

This shows a person holding their head in pain.

Featured Neurology Neuroscience Pain

·July 11, 2024·4 min read

New Discovery Links Protein to Chronic Pain

Researchers identified a new role for the PIEZO2 protein in mediating chronic pain hypersensitivity, suggesting a new target for pain relief. The study showed that mutations in PIEZO2 make pain receptors, or nociceptors, highly sensitive to mechanical stimuli, explaining persistent pain. This finding could lead to new analgesics that better address chronic pain by targeting PIEZO2 channels.

Featured Genetics Neuroscience Pain

·June 10, 2024·7 min read

Pruning Pain: Protein Associated with Pain Sensitivity Identified

The protein Kif2a acts as a "gardener" for sensory neurons, regulating their axon growth. This pruning process is crucial for managing pain sensitivity. The absence of Kif2a in genetically engineered mice resulted in increased axon density and heightened pain sensitivity over time. However, a compensatory mechanism reduces pain sensitivity in the long term, offering potential insights for chronic pain management.

Featured Neurology Neuroscience Pain

·May 25, 2024·3 min read

Aging Reduces Sensitivity to Heat Pain but Not Pressure Pain

Aging reduces sensitivity and discriminative ability for heat pain, but not pressure pain. Researchers compared pain perception in young and older adults using heat and pressure stimuli.

Featured Neurology Neuroscience Pain

·April 22, 2024·5 min read

Socioeconomic Factors Linked to Chronic Pain

Socioeconomic status, lifestyle, and psychological factors significantly influence the development of chronic musculoskeletal pain after injury. The study found that individuals from lower socioeconomic backgrounds are twice as likely to experience chronic pain, and those with additional risk factors such as smoking, fear of movement, and poor support networks are up to seven times more likely.

Featured Neurology Neuroscience Pain Psychology

·March 12, 2024·6 min read

AI and Mindfulness: A New Way to Manage Pain

A new study examines the potential of artificial intelligence to shift chronic pain treatment from opioids to mindfulness-based stress reduction (MBSR). Utilizing machine learning to analyze extensive patient data, the study aims to predict which patients will benefit most from MBSR, a critical step towards personalized medicine.

Featured Neuroscience Pain

·February 6, 2024·5 min read

Schwann Cells Key to Touch and Pain

Schwann cells, previously known for their role as insulators around nerve fibers, are actively involved in detecting sensory stimuli such as touch and pain. This groundbreaking study reveals that specific types of Schwann cells form a network just beneath the skin's surface, directly connecting to nerve endings responsible for sensing mechanical pressure.